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首页> 外文会议>2011 1st Middle East Conference on Biomedical Engineering >Superparamagnetic iron oxides formulated in polylactide-co-glycolide/ D-alpha-tocopherol polyethylene glycol 1000 succinate (PLGA/TPGS) nanoparticles for high contrast MRI
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Superparamagnetic iron oxides formulated in polylactide-co-glycolide/ D-alpha-tocopherol polyethylene glycol 1000 succinate (PLGA/TPGS) nanoparticles for high contrast MRI

机译：聚乳酸-乙交酯/D-α-生育酚聚乙二醇1000琥珀酸酯（PLGA / TPGS）纳米粒子中配制的超顺磁性氧化铁，用于高对比度MRI

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摘要

Nano-sized polymeric drug carriers have played promising part for improving the therapeutic effect of drug by providing the drug, properties to enact in a sustained and long circulating manner. Iron oxide (IOs) nanoparticles on the other hand are useful in biomedicine for T2-weigheted magnetic resonance imaging (MRI), to visualize fine details using MRI especially the reticulo-endothelial system (RES), the place where they accumulate the most after administration. The idea of this work is to combine the sustained and long circulating property of the polymeric nanoparticles on the functionality of the IOs, so as to provide long circulating MRI contrast agent. We have used PLGA (a co-polymer of lactic acid and glycolic acid) as a model polymer, D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) as surfactant and hydrophobic IOs synthesized by thermal decomposition. Encapsulation of IOs in the polymer matrix was done using a modified nanoprecipitation method, the difference in chemistry between the drug and the IOs was exploited, and parameter optimization was done, the IOs distribution in the polymeric matrix was observed to vary with the method of choice i.e. single emulsion method or nanoprecipitation method. The synthesized IOs PLGA/TPGS hybrid nanoparticles were tested invivo using xenograft mice for their ability to target tumour through enhanced permeability and retention (EPR).
机译：纳米尺寸的聚合物药物载体通过提供药物，以持续和长期循环的方式起作用的特性，在改善药物治疗效果方面发挥了有希望的作用。另一方面，氧化铁（IOs）纳米颗粒可用于T2加权磁共振成像（MRI）的生物医学中，以使用MRI可视化精细细节，尤其是网状内皮系统（RES），即给药后它们最多积累的地方。这项工作的想法是将聚合物纳米颗粒的持续和长循环特性结合到IO的功能上，从而提供长循环MRI造影剂。我们使用PLGA（乳酸和乙醇酸的共聚物）作为模型聚合物，使用D-α-生育酚聚乙二醇1000琥珀酸酯（TPGS）作为表面活性剂和通过热分解合成的疏水性IO。使用改良的纳米沉淀法将IOs封装在聚合物基质中，利用药物和IOs之间的化学差异，并进行了参数优化，观察到IOs在聚合物基质中的分布随选择的方法而变化即单乳液法或纳米沉淀法。使用异种移植小鼠体内测试了合成的IOs PLGA / TPGS杂化纳米颗粒通过增强的通透性和保留（EPR）靶向肿瘤的能力。

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