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A Collagen-Based Matrix that Enhances Cardiac and Skeletal Myogenesis in Mouse Embryonic Stem Cells

机译:基于胶原蛋白的基质,可增强小鼠胚胎干细胞的心脏和骨骼肌形成。

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These results demonstrate that the collagen matrix enhanced skeletal myogenesis, indicated by increased numbers of multinucleated myotubes and upregulation of skeletal muscle markers. The sLe* -modification of the collagen matrix enhanced cardiomyogenesis in mouse ES cells, shown by increased beating and upregulation of cardiogenic genes. Thus we have identified biomaterials that could serve a two-fold purpose of providing an injectable substrate for delivery of stem cells and enhancing the progenitor population of both cardiac and skeletal muscles.
机译:这些结果表明,胶原蛋白基质增强了骨骼肌的形成,其表现为多核肌管数量的增加和骨骼肌标志物的上调。胶原蛋白基质的sLe *修饰增强了小鼠ES细胞的心肌发生,表现为心跳基因的跳动和上调增加。因此,我们已经确定了生物材料,其可以提供双重目的,即提供可注射的底物用于递送干细胞并增强心肌和骨骼肌的祖细胞群。

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