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首页> 外文会议>33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method
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Localization of ictal onset zones in Lennox-Gastaut syndrome using directed transfer function method

机译：使用定向传递函数法定位Lennox-Gastaut综合征的发作期区域

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Neuroscientists are becoming interested in the application of computational EEG analysis to the identification of ictal onset zones, however, most studies have focused on the localization of ictal onset zones in focal epilepsy. The present study aimed to estimate the ictal onset zone of Lennox-Gastaut syndrome (LGS) with bilaterally synchronous epileptiform discharges from intracranial electroencephalography (iEEG) recordings using directional connectivity analysis. We analyzed ictal iEEG data acquired from three patients with LGS. To identify the ictal onset zones, we estimated the functional directional connectivity network among the intracerebral electrodes using the directed transfer function (DTF) method. The analysis results demonstrated that areas with high average outflow values corresponded well with the surgical resection areas identified using electrophysiologic data and conventional neuroimaging modalities. Our results suggest that the DTF analysis can be a useful auxiliary tool for determining surgical resection areas prior to epilepsy surgery in LGS patients.
机译：神经科学家对将计算性脑电图分析应用于发作发作区的识别越来越感兴趣，但是，大多数研究都集中在局灶性癫痫发作发作区的定位上。本研究旨在通过定向连通性分析从颅内脑电图（iEEG）记录中估计双侧同步癫痫样放电的Lennox-Gastaut综合征（LGS）的发作期区域。我们分析了从三名LGS患者中获得的早期iEEG数据。为了确定发作期区域，我们使用定向传递函数（DTF）方法估算了脑内电极之间的功能性定向连接网络。分析结果表明，具有高平均流出值的区域与使用电生理数据和常规神经影像学方法确定的手术切除区域非常吻合。我们的结果表明DTF分析可以作为LGS患者癫痫手术前确定手术切除区域的有用辅助工具。

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