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首页> 外文会议>33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Effects of spatial and temporal parameters of primary afferent microstimulation on neural responses evoked in primary somatosensory cortex of an anesthetized cat
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Effects of spatial and temporal parameters of primary afferent microstimulation on neural responses evoked in primary somatosensory cortex of an anesthetized cat

机译：初级传入微刺激的时空参数对麻醉猫初级体感皮层诱发的神经反应的影响

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摘要

Patterned microstimulation of muscle and cutaneous afferent neurons may provide tactile and proprioceptive feedback to users of advanced prosthetic limbs. However, it is unclear what types of stimulation patterns will be effective, and the parameter space for creating these patterns is prohibitively large to explore systematically using only psychophysics paradigms. In this study, we used an array of microelectrodes in primary somatosensory cortex (S1) of an isoflurane anesthetized cat to measure responses in a population of neurons evoked by various patterns of primary afferent microstimulation delivered to the L6 and L7 dorsal root ganglia (DRG). Each pattern consisted of a 300 ms train of microstimulation pulses having a fixed amplitude, pulse rate, and location in the array of DRG electrodes. Evoked responses were detectable on many S1 channels at the lowest amplitude tested (5 μA) and pulse rate (10 pulses per second). Increasing the pulse rate lowered the threshold amplitude for evoking a response on some S1 channels. Location effects were also observed. Adjacent stimulation sites evoked discriminable responses at low but not high (20 μA) amplitudes. In summary, we observed interactions between stimulation pulse rate, pulse amplitude, and location. Such interactions must be considered when designing stimulation patterns for transmitting sensory feedback by primary afferent microstimulation.
机译：肌肉和皮肤传入神经元的图案化微刺激可以为高级假肢使用者提供触觉和本体感受反馈。然而，尚不清楚哪种类型的刺激模式将是有效的，并且仅使用心理物理学范式来系统地探索，创建这些模式的参数空间就非常大。在这项研究中，我们在异氟烷麻醉的猫的初级体感皮层（S1）中使用了一系列微电极，以测量由传递至L6和L7背根神经节（DRG）的各种初级传入微刺激模式引起的神经元群体中的反应。 。每个模式由300 ms的一系列微刺激脉冲组成，这些脉冲具有固定的幅度，脉冲频率以及在DRG电极阵列中的位置。在许多S1通道上，以最低的测试振幅（5μA）和脉冲速率（每秒10个脉冲）可以检测到诱发的响应。增加脉冲率会降低阈值幅度，以引起某些S1通道上的响应。还观察到位置效应。相邻的刺激位点在低但不高（20μA）的振幅下引起可分辨的响应。总之，我们观察到刺激脉冲频率，脉冲幅度和位置之间的相互作用。当设计刺激模式以通过初级传入微刺激传输感官反馈时，必须考虑这种相互作用。

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