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首页> 外文会议>European conference of the International Federation for Medical and Biological Engineering >Controlled Release and Antimicrobial Study of zinc(II)-Ion from zinc/poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hybrid Hydrogels
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Controlled Release and Antimicrobial Study of zinc(II)-Ion from zinc/poly(2-Hydroxyethyl Acrylate/Itaconic Acid) Hybrid Hydrogels

机译：锌/聚（2-羟乙基丙烯酸乙酯/衣康酸）杂化水凝胶中锌（II）-离子的控释和抗菌研究

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A novel zinc/poly(2-hydroxyethyl acry-late/itaconic acid) (Zn/P(HEA/IA)) hybrid hydrogels were successfully prepared by free radical crosslinking copolymeri-zation of 2- hydroxyethyl acrylate (HEA) and itaconic acid (IA) monomers. Zn(II)-ions were subsequently embeded by swelling dry gels in zinc salt solution. Zinc ions are of biomedi-cal importance due to their essential role for sustaining living organisms as well as for their anti-inflammatory and antimicrobial properties. Swelling studies were performed in vitro, in order to evaluate zinc ion effect on fluid diffusion into hydrogels. Observations from swelling studies indicate that in-termolecular interactions, such as coordinate bonding between Zn(II) and carboxyl and hydroxyl groups further stabilize the hybrid structure to a certain extent. Values of equilibrium degrees of swelling (qe) of Zn/P(HEA/IA) hybrid hydrogels depend on itaconic acid content. The release of the Zn(II)-ions from the hybrids was investigated in vitro, for a time period of seven days. The release profiles of Zn(II)-ions from the Zn/P(HEA/IA) hybrid hydrogels have shown a two-phase exponential profile with fast initial phase followed by a slower rate of release, reaching a plateau. The antimicrobial activity of the samples tested using E. coli pathogen showed satisfactory antimicrobial potential of Zn-loaded hybrid hydrogels. The obtained results have shown that such a new type of Zn/P(HEA/IA) hybrid hydrogels Therefore, hydrogels enriched with zinc ions system holds wide potential for application in clinic as an antibacterial biomaterial.
机译：通过丙烯酸2-羟乙酯（HEA）与衣康酸（ IA）单体。随后通过将干凝胶溶胀在锌盐溶液中来嵌入Zn（II）离子。锌离子具有生物医学重要性，因为它们对于维持生命有机体以及其抗炎和抗微生物特性至关重要。为了评估锌离子对流体扩散到水凝胶中的作用，在体外进行了溶胀研究。溶胀研究的观察结果表明，分子间的相互作用（例如Zn（II）与羧基和羟基之间的配位键合）在一定程度上进一步稳定了杂化结构。 Zn / P（HEA / IA）杂化水凝胶的溶胀平衡度（qe）值取决于衣康酸的含量。体外研究了杂合体中Zn（II）离子的释放，持续了7天。 Zn / P（HEA / IA）杂化水凝胶中Zn（II）离子的释放曲线显示出两相指数曲线，其初始相快速，随后释放速度较慢，达到了平稳状态。使用大肠杆菌病原体测试的样品的抗菌活性显示出载有Zn的杂化水凝胶具有令人满意的抗菌潜力。获得的结果表明，这种新型的Zn / P（HEA / IA）杂化水凝胶，因此，富含锌离子系统的水凝胶作为抗菌生物材料在临床上具有广阔的应用前景。

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