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INCREASING DRUG RELEASE RATE THROUGH FOAMED STRUCTURES

机译:通过泡沫结构提高药物释放速率

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摘要

The influence of foam morphology on the release rate of Indomethacin (INM) from a solid solution prepared by hot melt extrusion was investigated. Closed cell foams were produced through a batch process, employing CO2 as physical blowing agent. In all cases foamed disks showed faster INM's release than un-foamed disks. The time required for completing INM's release was reduced up to 75% mainly due to extensive and random breakage of the sample during dissolution test.
机译:研究了泡沫形态对吲哚美辛(INM)从热熔挤出制备的固溶体中释放速率的影响。闭孔泡沫是通过分批工艺生产的,采用CO2作为物理发泡剂。在所有情况下,发泡磁盘显示的INM释放速度都比未发泡磁盘快。完成INM释放所需的时间最多减少了75%,这主要是由于在溶出度测试期间样品的广泛和随机破裂。

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