We developed a highly efficient and clogging-free cells separation microfluidic chip based on their size and deformability. Currently, cells separation is categorized either by hydrodynamic or using filtration. Hydrodynamic cell separation manipulates flow for separation process based on cell size. Whereas filtration technique with microstructure constriction to separate the cells based on size and deformability which is known in relation to cell phenotypes. However, size based separation techniques suffer from clogging and fouling issues.
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