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Pharmacotherapy for smoking cessation - The experience of a smoking cessation center

机译：戒烟药物疗法-戒烟中心的经验

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Smoking is a major public health problem with medical, social, and financial implications. We conducted a retrospective analysis of data resulting from enrollment and completion of a smoking cessation program of a number of 399 subjects of both gender, who presented consecutively in 2009 to the Smoking Cessation Counseling Medical Office of the Iasi Clinical Rehabilitation Hospital. The treatment for smoking cessation was represented either by bupropion or varenicline, administered by the usual scheme. Smoking severity was quantified by pack - years, determining the carbon monoxide in the exhaled air, both at baseline and at the end of the treatment period, and by Fagerström test for nicotine dependence. In female patients, the severity of smoking was significantly lower (P = 0.000) but their male counterparts responded better to treatment. Also, varenicline seemed to have a stronger therapeutic effect then bupropion while their adverse effects were similar.
机译：吸烟是一个重大的公共卫生问题，具有医学，社会和经济意义。我们对纳入和完成的399名男女受试者戒烟计划的数据进行了回顾性分析，这些受试者于2009年连续向雅西临床康复医院的戒烟咨询医学办公室提出。戒烟治疗以安非他酮或伐尼克兰为代表，采用常规方案进行治疗。吸烟的严重程度通过包装-年进行定量，确定基线和治疗期结束时呼出空气中的一氧化碳，并通过Fagerström烟碱依赖性试验进行定量。在女性患者中，吸烟的严重程度明显降低（P = 0.000），但男性患者对治疗的反应更好。同样，伐尼克兰似乎比安非他酮有更强的治疗作用，而它们的不良反应相似。

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