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首页> 外文会议>International IEEE/EMBS Conference on Neural Engineering >Adaptation and Optimization of an Intraneural Electrode to Interface with the Cervical Vagus Nerve
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Adaptation and Optimization of an Intraneural Electrode to Interface with the Cervical Vagus Nerve

机译：颈部电极与宫颈迷走神经界面的适应性和优化

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The modulation of the cervical vagus nerve (VN) using neural electrodes has shown great potential to treat cardiovascular, inflammatory, intestinal, or respiratory dysfunctions. Intraneural electrodes have shown great potentials for other neuroprosthetic applications. Therefore, their use for VN modulation could have great potential. Here we optimized an intraneural electrode originally developed for use in lower limb amputees. Based on histological data from the VN of 100 histological sections we adapted and optimized the dimensions of the Quick-to-implant peripheral neural electrode (Q-PINE). Parts of the Q-PINE were substituted to increase biocompatibility. The platinum-iridium (Pt/Ir) wires were substituted with a polyimide thin-film structure to optimize the electrodes' impedance. Mechanical and electrochemical characterization was performed to exclude negative alterations resulting from the design and material changes. The dimensional adaptation and material substitutions of the Q-PINE did not alter its mechanical or electrochemical properties. The tf-QPINE shows promising results for the successful application with the VN.
机译：使用神经电极的宫颈迷走神经（VN）的调节显示了治疗心血管，炎症，肠道或呼吸功能障碍的巨大潜力。内部电极显示出其他神经高原素应用的巨大潜力。因此，它们对VN调制的用途可能具有很大的潜力。在这里，我们优化了最初开发用于下肢肢体的内部电极。基于来自100个组织学部分的VN的组织学数据，我们改进并优化了快速植入外围神经电极（Q-松）的尺寸。 Q-Pine的部分被取代以增加生物相容性。用聚酰亚胺薄膜结构取代铂 - 铱（Pt / IR）线以优化电极的阻抗。进行机械和电化学表征以排除由设计和材料改变产生的负变化。 Q-Pine的尺寸适应和材料取代没有改变其机械或电化学性质。 TF-QPine显示了与VN成功应用的有希望的结果。

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