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Analysis of a baroreflex model for the study of the chronotropic response to vagal nerve stimulation

机译:对迷走神经刺激的时程度反应研究的缩减反应性模型分析

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This paper describes the integration of computational models of the cardiovascular system, the cardiac electrical activity and the baroreceptor reflex of the autonomic nervous system, with a model representing vagal nerve stimulation (VNS). Sensitivity analyses are performed in order to find the model parameters that produce significant effects on heart rate (chronotropic effect). The most significant parameters are adjusted in order to reproduce real data acquired from sheep suffering from heart failure, during VNS periods. Results show the potential of the model to generate realistic chronotropic responses to VNS.
机译:本文介绍了心血管系统的计算模型,心动发力和自主神经系统的丧腿反射的计算模型,具有代表迷走神经刺激(VNS)的模型。进行敏感性分析,以便找到对心率产生显着影响的模型参数(时程效应)。在VNS时段期间调整最重要的参数,以便再现从患有心力衰竭的绵羊获取的真实数据。结果显示模型的潜力,以产生对VNS的现实顺从响应。

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