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NANOMATERIALS AS NANOCOMPOSITE FILLERS: CYTOTOXICITY AT DIFFERENT STAGES OF THEIR LIFE CYCLE

机译:纳米材料作为纳米复合填料:其生命周期不同阶段的细胞毒性

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MWCNT and SiO_2 NP are widely used as nanofillers in polymeric matrices for different applications. We have studied the cytotoxicity of these NM at the different stages of the life cycle in A549 and HepG2 cell lines. To evaluate NM (MWCNT and SiO_2 NP) at the different stages of the life cycle, these NM were recovered from the polymer matrix by different processes, either by calcination of the polymer nanocomposite or by dissolution followed by filtration or centrifugation. These processes induced surface modification on the NM that were reflected in their toxicological profile. In the case of MWCNT calcination processes leaded to higher cytotoxicity and for hydrophilic SiO_2 NP after the have been recovered by calcination they are not cytotoxic anymore. Surface chemistry is driving the cytotoxic effects of NM along their life cycle.
机译:MWCNT和SiO_2 NP被广泛用作聚合物基质中的纳米填料,用于不同的应用。我们已经研究了这些NM在A549和HepG2细胞系生命周期不同阶段的细胞毒性。为了评估生命周期不同阶段的NM(MWCNT和SiO_2 NP),可以通过不同的方法从聚合物基质中回收这些NM,方法是煅烧聚合物纳米复合材料或通过溶解,然后过滤或离心。这些过程在NM上引起表面改性,这在其毒理学特征中得到反映。在MWCNT煅烧过程导致更高的细胞毒性的情况下,对于通过煅烧回收的亲水性SiO_2 NP,它们不再具有细胞毒性。表面化学正在推动NM在其生命周期中的细胞毒性作用。

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