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首页> 外文会议>Annual NSTI nanotechnology conference and expo >Zinc Oxide Nanoparticles Induce Apoptosis and Necrosis in Hepatocellular Carcinoma HepG2 Cells
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Zinc Oxide Nanoparticles Induce Apoptosis and Necrosis in Hepatocellular Carcinoma HepG2 Cells

机译：氧化锌纳米颗粒诱导肝癌细胞HepG2细胞凋亡和坏死。

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Targeted drug delivery systems with minimal potential adverse/side effects are gaining utility in diverse applications. Uses of nanomaterials to design such targeted drug delivery are escalating exponentially. Nevertheless, the biocompatibility of nanomaterials is inadequately addressed. Consequently, among our systematic investigation of putative cytotoxic effects of nanomaterials in mammalian cell types, this study aims to elucidate mechanisms underlying the putative cytotoxic effects of ZnO nanoparticles in hepatocellular carcinoma HepG2 cells. Our results demonstrate that these nanoparticles exerted dose-related decreases in survival of HepG2 cells. Findings from flow cytometry analysis and lactate dehydrogenase release assays reveal that the mode of cell death underlying the effects of the nanoparticle was a combination of apoptotic and necrotic cell death, while the percentage of necrotic cells predominated at higher treatment concentrations. Thus, our findings may have pathophysiological implications in biocompatibility of ZnO nanoparticles.
机译：具有最小潜在不良/副作用的靶向药物递送系统正在各种应用中获得实用性。纳米材料用于设计此类靶向药物的用途正呈指数级增长。然而，纳米材料的生物相容性并未得到充分解决。因此，在我们对纳米材料在哺乳动物细胞类型中的假定细胞毒性作用的系统研究中，本研究旨在阐明ZnO纳米粒子在肝细胞癌HepG2细胞中的假定细胞毒性作用的机制。我们的结果表明，这些纳米颗粒在HepG2细胞的存活中发挥了剂量相关的降低作用。从流式细胞仪分析和乳酸脱氢酶释放分析发现，纳米颗粒作用的细胞死亡模式是凋亡和坏死细胞的组合，而在较高的治疗浓度下坏死细胞的百分比占主导。因此，我们的发现可能对ZnO纳米颗粒的生物相容性具有病理生理学意义。

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