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A direct derivative method for estimating kinetic parameters of biological networks

机译:一种估算生物网络动力学参数的直接衍生方法

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Challenged by strong nonlinearity of cellular network models, large uncertainty in model parameters, and noisy experimental data, a new parameter estimation algorithm, direct derivative method (DDM), is presented in which the measurement data are firstly fitted with smoothing splines, and then the first-order derivative of state variables are evaluated and substituted into the model. Thus, a dynamic optimization problem is converted into a linear or nonlinear regression problem. There is no need to solve ordinary differential equations of the system models iteratively, the computational complexity is therefore reduced to a large extent. Taking the IκBα-NF-κB signal transduction pathways as an example, unknown parameters are estimated effectively using the proposed DDM algorithm, and various factors that affect the results are investigated.
机译:通过蜂窝网络模型的强非线性挑战,模型参数的大不确定性以及嘈杂的实验数据,提出了一种新的参数估计算法,直接导数方法(DDM),其中测量数据首先配有平滑的样条,然后态变量的一阶导数被评估并替换为模型。因此,动态优化问题被转换为线性或非线性回归问题。因此,不需要迭代地解决系统模型的常微分方程,因此计算复杂性在很大程度上降低。采用IκBα-NF-κB信号转导途径作为示例,使用所提出的DDM算法有效地估计未知参数,并研究了影响结果的各种因素。

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