Harnessing sphingosine-1-phosphate signaling and nanotopographical cues to regulate skeletal muscle maturation and vascularization

机译：利用鞘氨醇-1-磷酸三磷酸线信号和纳米波特调节，以调节骨骼肌成熟和血管化

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Conclusions: We have demonstrated that by harnessing signaling cues from biomimetic nanotopography and from S1P, it is possible to enhance the maturation and overall function of cultured skeletal muscle progenitors in conjunction with an enhanced neovascularization capability, all without the need for incorporating multiple large proteins or growth factors. In future work, by combining S1P signaling with cell-sheet fabrication techniques that enable the generation of highly-ordered 3D tissues, we aim to generate skeletal muscle tissues that are primed for prolonged myogenic development and vascularization in vivo.

机译：结论：我们已经证明，通过利用从仿生纳米发作和S1P的信号线提示，可以提高培养的骨骼肌祖细胞与增强的新血管形成能力的成熟和整体功能，无需掺入多种大蛋白质或生长因素。在将来的工作中，通过将S1P信号与细胞片制造技术组合，使得能够产生高度有序的3D组织，我们的目的是产生骨骼肌组织，该肌肉组织被促进用于长期肌原遗传发育和体内血管化。

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《Society for Biomaterials annual meeting and exposition》|2017年|851 p.|共1页
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Jonathan H. Tsui; Kajohnkiart Janebodin; Nicholas Ieronimakis; David M. P. Yama; Hee Seok Yang; Rakchanok Chavanachat; Aislinn L. Hays; Morayma Reyes; Deok-Ho Kim;
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1. Harnessing Sphingosine-1-Phosphate Signaling and Nanotopographical Cues To Regulate Skeletal Muscle Maturation and Vascularization [J] . Tsui Jonathan H., Janebodin Kajohnkiart, Ieronimakis Nicholas, ACS nano . 2017,第12期

机译：利用鞘氨醇-1-磷酸磷酸型信号和纳米波特调节，调节骨骼肌成熟和血管化
2. The influence of sphingosine-1-phosphate receptor signaling on lymphocyte trafficking: How a bioactive lipid mediator grew up from an “immature” vascular maturation factor to a “mature” mediator of lymphocyte behavior and function [J] . Michael D. Davis, John H. Kehrl Immunologic Research . 2009,第1a3期

机译：鞘氨醇-1-磷酸受体信号传导对淋巴细胞运输的影响：生物活性脂质介体如何从“未成熟”的血管成熟因子成长为淋巴细胞行为和功能的“成熟”介体
3. The influence of sphingosine-1-phosphate receptor signaling on lymphocyte trafficking: How a bioactive lipid mediator grew up from an "immature" vascular maturation factor to a "mature" mediator of lymphocyte behavior and function. [J] . Davis MD, Kehrl JH Immunologic Research: A Selective Reference to Current Research and Practice . 2009,第1a3期

机译：鞘氨醇-1-磷酸受体信号传导对淋巴细胞运输的影响：生物活性脂质介体如何从“未成熟的”血管成熟因子成长为淋巴细胞行为和功能的“成熟”的介体。
4. Harnessing sphingosine-1-phosphate signaling and nanotopographical cues to regulate skeletal muscle maturation and vascularization [C] . Jonathan H. Tsui, Kajohnkiart Janebodin, Nicholas Ieronimakis, Society for Biomaterials annual meeting and exposition . 2017

机译：利用鞘氨醇-1-磷酸信号和纳米形线索来调节骨骼肌的成熟和血管形成
5. Wnt signaling in skeletal muscle regeneration is modulated by a MEF2A-regulated miRNA mega-cluster. [D] . Snyder, Christine Marie. 2012

机译：骨骼肌再生中的Wnt信号传导受MEF2A调节的miRNA巨型簇调控。
6. Harnessing Sphingosine-1-Phosphate Signaling and Nanotopographical Cues to Regulate Skeletal Muscle Maturation and Vascularization [O] . Jonathan H. Tsui, Kajohnkiart Janebodin, Nicholas Ieronimakis, -1

机译：利用鞘氨醇-1-磷酸信号和纳米拓扑线索来调节骨骼肌成熟和血管化。
7. Harnessing Sphingosine-1-Phosphate Signaling and Nanotopographical Cues To Regulate Skeletal Muscle Maturation and Vascularization [O] . -1

机译：利用鞘氨醇-1-磷酸三磷酸线信号和纳米波特调节，以调节骨骼肌成熟和血管化

Harnessing sphingosine-1-phosphate signaling and nanotopographical cues to regulate skeletal muscle maturation and vascularization

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