Targeted delivery of nanoparticles as a treatment for emphysema

机译：纳米颗粒的靶向递送作为肺气肿的治疗方法

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This result suggests that PGG plays an important role in preserving elastin in the tissue. Delivery of PGG NPs to mild emphysema mice model protected elastin from degradation and retained lung compliance the same as control healthy animals. This suggests PGG, when delivered locally by targeted nanoparticles, has the potential to stabilize elastin against elastases. Given its central role in the development of emphysema, preservation of elastin in lungs is a novel and potential treatment option to halt disease progression.

机译：该结果表明PGG在保存组织中的弹性蛋白中起重要作用。将PGG NPS递送至轻度肺气肿小鼠模型保护的弹性蛋白免于降解，并保留肺顺从与对照健康动物相同。这表明PGG，当通过靶向纳米颗粒本地递送时，具有稳定弹性蛋白抵抗弹性酶的可能性。鉴于其在肺气肿的发展中的核心作用，肺部的弹性蛋白的保存是一种新颖的和潜在的治疗选择，可停止疾病进展。

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《Society for Biomaterials annual meeting and exposition》|2019年|p. 493-976|共1页
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Vaideesh Parasaram; Xiaoying Wang; Naren R. Vyavahare;
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Targeted delivery of nanoparticles as a treatment for emphysema

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