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Hydrogels with Differential and Patterned Mechanics to Study Stiffness-Mediated Myofibroblastic Differentiation of Hepatic Stellate Cells

机译：用差分和图案化力学的水凝胶研究僵硬介导的肝星状细胞的肌纤维囊肿分化

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Myofibroblastic differentiation of HSCs was observed for HSCs cultured on stiff substrates whereas on soft substrates the majority of the HSCs remained quiescent. This behaviour is directly correlated to cellular spreading such that on stiff substrates HSC morphology changes significantly with intense cellular spreading, whereas cells maintain their quiescent rounded morphology on soft substrates. Our results show that HSC cell spreading can be controlled by patterning stiffness where cells show significantly low spreading for circular stiff regions at diameters ≤ 100μm. This study shows that cell spreading plays an important role and is necessary for myofibroblastic differentiation of HSCs, even on a stiff substrate.

机译：对于在硬质基板上培养的HSCs，观察到HSCs的MyOfbrobrobrambro植化分化，而在软基板上的大部分HSC的HSC仍然静脉。该行为与细胞扩展直接相关，使得在刚性底物中，具有强烈的细胞扩展显着变化，而细胞在软基板上保持其静态圆形形态。我们的结果表明，通过图案化刚度来控制HSC电池扩散，其中细胞显示在直径≤100μm的圆形刚性区域的显着低展示。该研究表明，即使在硬基板上，细胞扩散也起着重要作用，并且对于HSCs的MyOfbrobrobrambrambro分化是必要的。

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《Society for Biomaterials annual meeting and exposition》|2014年||共1页
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Murat Guvendiren; Maryna Perepelyuk; Rebecca G. Wells; Jason A. Burdick;
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1. Hydrogels with differential and patterned mechanics to study stiffness-mediated myofibroblastic differentiation of hepatic stellate cells [J] . Murat Guvendiren, Maryna Perepelyufe, Rebecca G. Wells, Journal of the mechanical behavior of biomedical materials . 2014,第Null期

机译：具有差异和模式力学的水凝胶，用于研究刚度介导的肝星状细胞肌成纤维细胞分化
2. Cellular Retinol-Binding Protein-1 Expression and Modulation during In Vivo and In Vitro Myofibroblastic Differentiation of Rat Hepatic Stellate Cells and Portal Fibroblasts [J] . Kozue Uchio, Beatriz Tuchweber, Noboru Manabe, Laboratory investigation . 2002,第5期

机译：在大鼠肝星状细胞和门静脉成纤维细胞的体内和体外肌成纤维细胞分化过程中细胞视黄醇结合蛋白1表达和调节。
3. Cellular Retinol-Binding Protein-1 Expression and Modulation during In Vivo and In Vitro Myofibroblastic Differentiation of Rat Hepatic Stellate Cells and Portal Fibroblasts [J] . Kozue Uchio, Beatriz Tuchweber, Noboru Manabe, Laboratory investigation . 2002,第5期

机译：在大鼠肝星状细胞和门静脉成纤维细胞的体内和体外肌成纤维细胞分化过程中细胞视黄醇结合蛋白1表达和调节。
4. Hydrogels with Differential and Patterned Mechanics to Study Stiffness-Mediated Myofibroblastic Differentiation of Hepatic Stellate Cells [C] . Murat Guvendiren, Maryna Perepelyuk, Rebecca G. Wells, Society for Biomaterials annual meeting and exposition . 2014

机译：具有差异和模式力学的水凝胶，用于研究刚度介导的肝星状细胞肌成纤维细胞分化
5. Histone deacetylase 4 represses matrix metalloproteinases in myofibroblastic hepatic stellate cells. [D] . Qin, Lan. 2010

机译：组蛋白脱乙酰基酶4抑制成肌纤维母细胞肝星状细胞中的基质金属蛋白酶。
6. Hydrogels with Differential and Patterned Mechanics to Study Stiffness-Mediated Myofibroblastic Differentiation of Hepatic Stellate Cells [O] . Murat Guvendiren, Maryna Perepelyuk, Rebecca G. Wells, -1

机译：具有差异和模式力学的水凝胶用于研究刚度介导的肝星状细胞肌成纤维细胞分化
7. Cellular Retinol-Binding Protein-1 Expression and Modulation during In Vivo and In Vitro Myofibroblastic Differentiation of Rat Hepatic Stellate Cells and Portal Fibroblasts [O] . Kozue Uchio, Beatriz Tuchweber, Noboru Manabe, 2002

机译：细胞视黄醇结合蛋白-1在体内的表达和调节和大鼠肝星状细胞和门纹成纤维细胞的体外肌纤维细胞分化

Hydrogels with Differential and Patterned Mechanics to Study Stiffness-Mediated Myofibroblastic Differentiation of Hepatic Stellate Cells

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