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首页> 外文会议>Symposium on pesticide formulations and delivery systems >Fabric Challenge Assays: New Standards for the Evaluation of the Performance of Textiles Treated with Antimicrobial Agents
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Fabric Challenge Assays: New Standards for the Evaluation of the Performance of Textiles Treated with Antimicrobial Agents

机译：织物挑战试验：评估用抗菌剂处理的纺织品性能的新标准

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Textiles treated with antimicrobial agents are emerging as new strategies to reduce acquisition of healthcare-associated infections (HAIs). Essential to development/validation of these textiles are standard methods for the testing antimicrobial textile efficacy. Our laboratory has developed new testing methods, the fabric challenge assays, to recapitulate each transmission method and test the efficacy of antimicrobial textiles in a more "real world" simulation. 5 × 10~5 colony-forming units/ml (CFU/ml) MRSA suspensions were grown. 15 × 15 cm~2 swatches of control, antimicrobial, hydrophobic barrier, and VTT003 fabric were inoculated with MRSA either by aerosol, splatter, or direct contact. Inoculated fabric was left at room temperature for 0, 30, or 60 min. Fabric was then transferred to buffer and shaken for 3 min at 400 rpm. A liquid suspension (0.1 ml) was then plated onto blood agar, grown overnight at 37°C, and colonies were counted. In the aerosol test, at 0 min, VTT003 significantly reduced MRSA by 78.52 ± 10.26% compared to control fabric. At 30 min, antimicrobial reduced MRSA levels by 91.48 ± 8.52 %. In the splatter test, at 0 min, antimicrobial, hydrophobic barrier, and VTT003 fabrics reduced MRSA levels by 98.56 ± 1.44, 83.91 ± 13.16, and 100.00 ±0.03%, respectively. At 30 min, hydrophobic barrier and VTT003 reduced levels by 82.63 ±17.37 and 100.00 ±0.00%, respectively. At 60 min, hydrophobic barrier and VTT003 abrogated MRSA levels. In the contact test, at 0 min, hydrophobic barrier and VTT003 reduced MRSA levels by 99.06 ±0.94 and 97.08 ±2.92%, respectively. At 30 min, hydrophobic barrier and VTT003 reduced MRSA levels by 100.00 ±0.03 and 19.38± 19.38%, respectively. At 60 min, hydrophobic barrier and VTT003 abrogated MRSA levels. The fabric challenge assays are a novel method for evaluation of antimicrobial textile performance and should be considered in the development of standards and testing methods for all antimicrobial textiles intended for use in healthcare infection control strategies.
机译：用抗菌剂处理的纺织品正在作为减少对医疗保健相关感染（HAIs）的获取的新策略而兴起。这些纺织品的开发/验证必不可少的是测试抗菌纺织品功效的标准方法。我们的实验室开发了新的测试方法，即织物挑战测定法，以概括每种传输方法，并在更“真实的世界”模拟中测试抗菌纺织品的功效。生长5×10〜5个菌落形成单位/ ml（CFU / ml）MRSA悬浮液。用气溶胶，喷溅或直接接触的方法将15×15 cm〜2的对照，抗菌，疏水性屏障和VTT003织物样本接种​​MRSA。将接种的织物在室温下放置0、30或60分钟。然后将织物转移到缓冲液中，并在400 rpm下摇动3分钟。然后将液体悬浮液（0.1ml）铺在血琼脂上，在37℃下生长过夜，并计数菌落。在气雾剂测试中，与对照织物相比，在0分钟时，VTT003显着降低了MRSA 78.52±10.26％。在30分钟时，抗菌药物将MRSA水平降低了91.48±8.52％。在飞溅测试中，在0分钟时，抗菌，疏水性屏障和VTT003织物的MRSA含量分别降低了98.56±1.44、83.91±13.16和100.00±0.03％。在30分钟时，疏水性屏障和VTT003分别降低了82.63±17.37和100.00±0.00％的水平。在60分钟时，疏水性屏障和VTT003废除了MRSA水平。在接触测试中，在0分钟时，疏水性屏障和VTT003分别使MRSA水平降低了99.06±0.94和97.08±2.92％。在30分钟时，疏水性屏障和VTT003分别将MRSA水平降低了100.00±0.03和19.38±19.38％。在60分钟时，疏水性屏障和VTT003废除了MRSA水平。织物攻击试验是一种评估抗菌纺织品性能的新颖方法，在制定旨在用于医疗保健感染控制策略的所有抗菌纺织品的标准和测试方法时，应考虑采用这种方法。

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