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Early detection of cardiotoxicity in chemotherapy-treated patients from real-time 3D echocardiography

机译：实时3D超声心动图早期检测化疗患者的心脏毒性

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Cardiotoxicity is a well-known adverse effect of various chemotherapeutic agents that can be monitored by echocardiography. A decrease of left ventricular ejection fraction (LVEF) during the therapy might indicate dangerous effects of the drug on the myocardium and triggers consideration of therapy modification or interruption. We hypothesized myocardial deformation could identify preclinical myocardial dysfunction earlier than conventional LVEF allowing the administration of treatments to avoid cardiac side-effects. Sixty-five patients who were newly diagnosed with breast cancer, were enrolled to be evaluated by echocardiography before cancer therapy, during the therapy at 16 weeks (16w) and at follow up after 32 weeks (32w). Following the recommendation, 24 patients (36.9%) showed cardiotoxicity; 11 (16.9%) interrupted the therapy due to a severe cardiac dysfunction and at 32w only 4 patients recovered. In this group at 16w, strain analysis showed a significant reduction for all strain values that were all predictive of cardiotoxicity independently from LVEF and radial strain resulted an independent prognostic index of cardiotoxicity. The assessment of myocardial deformation indexes might provide additional echocardiographic tools to assess cardio-toxic effects beyond LVEF.

机译：心脏毒性是可以通过超声心动图监测的各种化学治疗剂的众所周知的副作用。治疗期间左心室射血分数（LVEF）的降低可能表明该药物对心肌有危险作用，并引发考虑修改治疗或中断治疗。我们假设心肌变形可以比常规LVEF更早地识别出临床前心肌功能障碍，从而可以进行治疗以避免心脏副作用。在癌症治疗之前，治疗期间第16周（16w）以及治疗后第32周（32w）的超声心动图检查中，对新诊断为乳腺癌的65例患者进行了评估。根据推荐，有24例患者（36.9％）表现出心脏毒性。 11名患者（16.9％）由于严重的心脏功能障碍而中断了治疗，并且在32周时仅有4名患者康复。在该组中，在16w时，应变分析显示所有可独立于LVEF预测心脏毒性的应变值均显着降低，而径向应变则产生了独立的心脏毒性预后指标。心肌变形指数的评估可能会提供其他超声心动图工具，以评估LVEF以外的心脏毒性作用。

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《Computing in Cardiology Conference》|2013年|249-252|共4页
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Lorenzini Cinzia; Corsi Cristiana; Aquilina Michele; Casadei Gardini Andrea;
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1. To study the usefulness and comparison of myocardial strain imaging by 2D and 3D echocardiography for early detection of cardiotoxicity in patients undergoing cardiotoxic chemotherapy [J] . Shamshad Alam, Sharad Chandra, Mahim Saran, Indian heart journal . 2019,第6期

机译：研究2D和3D超声心动图对心肌应变成像在早期检测心脏毒性化疗患者心脏毒性中的作用和比较
2. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. [J] . Sawaya H, Sebag IA, Plana JC, The American Journal of Cardiology . 2011,第9期

机译：化疗治疗患者的心脏毒性的早期发现和预测。
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机译：ISMP药物不良反应由安非他酮引起的泛发性皮疹性脓疱病，硫唑嘌呤引起的发烧可逆性后脑白质病综合征，舒尼替尼治疗与酮洛芬相关的非酒精性脂肪性肝病和脂肪性肝炎肾小球硬化合并急性肾转移性全血红蛋白血症伴急性肾衰老化疗患者心脏毒性的检测和预测
4. Early detection of cardiotoxicity in chemotherapy-treated patients from real-time 3D echocardiography [C] . Lorenzini Cinzia, Corsi Cristiana, Aquilina Michele, Computing in Cardiology Conference . 2013

机译：从实时3D超声心动图中早期检测化疗治疗患者的心脏毒性
5. Automated quantification of mitral valve morphology and dynamics using real-time 3D echocardiography. [D] . Pouch, Alison M. 2013

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机译：研究2D和3D超声心动图对心肌毒性的早期检测心肌毒性患者心肌毒性成像的有用性和比较
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Early detection of cardiotoxicity in chemotherapy-treated patients from real-time 3D echocardiography

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