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首页> 外文会议>International Conference on Image Processing Theory, Tools and Applications >Comparative study to analyze the effect of aging on microvascular blood flow by processing laser speckle contrast images when Lorentzian and Gaussian velocity profiles are assumed for moving scatterers
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Comparative study to analyze the effect of aging on microvascular blood flow by processing laser speckle contrast images when Lorentzian and Gaussian velocity profiles are assumed for moving scatterers

机译：在假定运动散射体的洛伦兹速度和高斯速度剖面时，通过处理激光散斑对比图像来分析衰老对微血管血流的影响的对比研究

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It is well known that microcirculation alters with age. These alterations can be evaluated by monitoring microvascular blood flow. Laser speckle contrast imaging (LSCI) is a recent optical imaging modality to monitor microvascular blood flow. From LSCI, the average velocity of microvascular moving scatterers (mainly red blood cells from the microcirculation) can be evaluated when assumptions on the scatterers velocity distribution are made. The objective of this study is twofold: 1) Process experimental LSCI data to compare velocity of red blood cells from the microcirculation when a Lorentzian profile and when a Gaussian profile are assumed. The experimental images that are processed have been recorded in healthy subjects, at rest, during a vascular occlusion and post-occlusive reactive hyperaemia, in two populations: young and aged subjects. 2) Analyze if alterations of microcirculation with age can be evaluated by processing LSCI data. Moreover, the presence of static scatterers (like skin) is taken into account in our work. Our results show that red blood cells velocity values determined when a Lorentzian velocity profile is assumed are lower than the ones determined when a Gaussian velocity profile is assumed, both for the young and the aged subjects. This is true with or without the presence of static scatterers. Furthermore, at rest, during biological zero, and post-occlusive reactive hyperaemia, the velocity of the moving scatterers increases with age. It also increases when the part of static scatterers increases. LSCI is therefore a new imaging modality that can be used to assess alterations of microvascular blood flow with age.
机译：众所周知，微循环会随着年龄而改变。这些改变可以通过监测微血管血流来评估。激光散斑对比度成像（LSCI）是一种用于监视微血管血流的最新光学成像方法。根据LSCI，当对散射体速度分布进行假设时，可以评估微血管运动散射体（主要是来自微循环的红细胞）的平均速度。这项研究的目的是双重的：1）处理实验LSCI数据，以比较假定洛伦兹曲线和高斯曲线时微循环中红细胞的速度。在两个人群中，年轻人群和老年人群中，健康受试者在静止时，血管闭塞和闭塞后反应性充血期间都记录了经过处理的实验图像。 2）分析是否可以通过处理LSCI数据评估微循环随年龄的变化。此外，在我们的工作中还考虑了静态散射体（如皮肤）的存在。我们的结果表明，无论是青年还是老年受试者，假设采用洛伦兹速度分布图时确定的红细胞速度值均低于假设采用高斯速度分布图时确定的红细胞速度值。无论是否存在静态散射体，这都是正确的。此外，在静止时，在生物学零和闭塞后反应性充血期间，运动散射体的速度随着年龄的增长而增加。当静态散射体的比例增加时，它也会增加。因此，LSCI是一种新的成像方式，可用于评估微血管血流量随年龄的变化。

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