• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Conference on reflection, scattering, and diffraction from surfaces >Spatially resolved spectral imaging of pharmaceutical powders
【24h】

Spatially resolved spectral imaging of pharmaceutical powders

机译：药物粉末的空间分辨光谱成像

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pharmaceutical initiatives use analytical tools to monitor powders flowing through granulating, blending, and tabletformation steps. Two critical parameters that drive the quality and efficiency of drugs are the concentration of actives inthe tablet, and the dissolution properties of the tablet. In order to ensure that these are within the target design space, it isimportant that component concentrations, particle size distributions, and cluster size are monitored throughout themanufacturing process. Standard optical techniques detect scattered light from spots that encompass many componentsin the blend. Efforts to extract composition and blend uniformity based on chemometric analyses are complex and oftenintractable. A highly spatially resolved spectral imager could simplify the chemometrics if the effective spatialresolution can separate most particles from neighboring particles. The effective spatial resolution is a function of theincident spot size, multiple scattering events, and the collection optics. This paper assesses the degree of spectral mixingdue to particle-particle scattering as a function of incident spot size. Our real-time optical design is enabled by a highspectral brightness supercontinuum source, a MEMs-based spectral scan mechanism, confocal spatial scanning optics,and high gain ~* bandwidth detection.
机译：药物举措使用分析工具监测流过造粒，混合和压片流动的粉末。推动药物质量和效率的两个关键参数是片剂活性物质的浓度，以及片剂的溶出性。为了确保这些在目标设计空间内，在整个实例制造过程中监测成分浓度，粒度分布和簇大小等重量。标准光学技术检测来自包含许多组件的斑点的散射光。基于化学计量分析提取组成和混合均匀性的努力是复杂的和经常的。如果有效的空间resolution可以将大多数颗粒与相邻颗粒分离，则高度空间分辨的光谱成像器可以简化化学计量学。有效的空间分辨率是神圣尺寸，多个散射事件和集合光学器件的函数。本文评估了光谱混合的程度，以颗粒颗粒散射作为入射点尺寸的函数。我们的实时光学设计由高光谱亮度超强源，基于MEMS的光谱扫描机构，共聚焦空间扫描光学和高增益〜*带宽检测。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号