• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International symposium on IT in medicine and education >Research on the Pharmacokinetics and Elimination of Epigallocatechin Gallate (EGCG) in Mice
【24h】

Research on the Pharmacokinetics and Elimination of Epigallocatechin Gallate (EGCG) in Mice

机译：小鼠中药（EGCG）的药代动力学和消除ePigallocateChin的研究

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The study was designed to investigate the metabolic kinetics and elimination of Epigallocatechin Gallate (EGCG) in mouse's tissues, basing on establishing a RP-HPLC method for determination of EGCG in mice plasma, liver, heart, spleen, kidney, pancreas, brain, testis, feces and urine. And the results showed that there was a good linearity over the range 0.1-200.0 mg/L (r ＞ 0.999) for plasma and 0.5-200.0 mg/kg (r ＞ 0.999) for other tissues. The recoveries were more than 85.0 % in all samples, and the intra-and inter-day coefficients of variation were less than 15.0 % in all cases. So the RP-HPLC method was readily applied for pharmacokinetics and elimination of EGCG in mice. EGCG was widely distributed in all the tissues of mice. But it was fast metabolized and eliminated from mice, and the main elimination way was metabolized by hydrolysis enzymes and excreted from urine.
机译：该研究旨在探讨小鼠组织中的代谢动力学和消除EpigallocateChin Gallate（EGCG），旨在建立RP-HPLC方法，用于测定小鼠血浆，肝，心脏，脾，肾，胰腺，脑，睾丸胰腺癌，粪便和尿液。结果表明，对于其他组织，血浆的0.1-200.0mg / L（r> 0.999）良好的线性度超过0.1-200.0mg / l（r> 0.999）。在所有样品中，回收率超过85.0％，并且在所有情况下，变异的内部变异系数和日内的变异系数小于15.0％。因此，RP-HPLC方法很容易施用于药代动力学和小鼠中的EGCG。 EGCG广泛分布在小鼠的所有组织中。但它从小鼠中快速代谢和消除，并且通过水解酶代谢并从尿液排出的主要消除方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号