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首页> 外文会议>Annual conference of the International Society of Exposure Science >Carotid intima-media thickness is associated with long-term exposures to PM10 and PM2.5 among middle-aged adults
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Carotid intima-media thickness is associated with long-term exposures to PM10 and PM2.5 among middle-aged adults

机译：颈动脉内膜中层厚度与中年成年人长期暴露于PM10和PM2.5相关

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Background: The association between long-term exposure to air pollution and carotid intima-media thickness (CIMT) is still inconsistent. Aims: To evaluate the association between one-year averaged exposure of particulate matters (PM) and the CIMT in adults without coronary diseases. Materials and Methods: We enrolled 402 adults aged 35-60 to participate in this study in Taipei, Taiwan during 2009-2011. We used a high-resolution B-mode ultrasonography to measure study subject's CIMT. We applied Land Use Regression models (LUR), which was developed by the European Study of Cohorts for Air Pollution Effects (ESCAPE), to estimate each subject's one-year averaged exposures of traffic-related air pollutants, including PM with diameters less than 10 mm (PM10) and 2.5 mm (PM2.5), and the absorbance of PM2.5 (PM2.5 abs), in urban environment. We applied multivariate linear regression analyses to assess the associations between air pollution exposures and CIMT adjusting for age, gender, systolic blood pressure, low-density iipoprotein cholesterol, body mass index, diabetes mellitus, education, and smoking. Results: Our study subjects with mean age of 47 years were mostly males (85%) with relatively low prevalence of hypertension (21.6%), diabetes mellitus (10.2%) and current smoking (14.4%). Their mean and maximum CIMT of left common carotid artery (CIMTLCCA) was 0.56±0.10 mm and 0.70±0.12 mm respectively. Their one-year averaged exposures ± standard deviations were 54.31± 5.99 μg/m3 for PM10, 28.74± 3.87 μg/m3 for PM2.5, and 2.14 ± 0.36 × 10-5m-1for PM2.5 abs. Multivariate regressions showed average percentage (95% confidence intervals) increase in mean CIMTLCCA was 2.51% (0.47-4.52%) per 5μg/m3 PM2.5, 5.03% (0.60-9.47%) per1.0 × 10-5m-1PM2.5 abs, and 2.69 % (0.05-5.32%) per 10 μg/m3 PM10, respectively. Conclusions: Subclinical atherosclerosis, represented by CIMT, was positively associated with long-term exposures to traffic-related PM2.5, PM2.5 abs, PM10 for middle-aged adults.
机译：背景：长期暴露于空气污染与颈动脉内中膜厚度（CIMT）之间的关联仍然不一致。目的：评估没有冠心病的成年人一年平均颗粒物暴露量（PM）与CIMT之间的关系。资料和方法：我们在2009-2011年期间招募了402位35-60岁的成年人参加了这项研究。我们使用高分辨率的B型超声检查来衡量研究对象的CIMT。我们应用了由欧洲空气污染影响研究组（ESCAPE）开发的土地利用回归模型（LUR）来估算每个受试者一年与交通相关的空气污染物的平均暴露量，包括直径小于10的PM毫米（PM10）和2.5毫米（PM2.5），以及在城市环境中PM2.5的吸光度（PM2.5 abs）。我们应用了多元线性回归分析来评估空气污染暴露与CIMT之间的关联，以调整年龄，性别，收缩压，低密度脂蛋白胆固醇，体重指数，糖尿病，教育程度和吸烟率。结果：我们的平均年龄为47岁的研究对象主要是男性（85％），其高血压的患病率相对较低（21.6％），糖尿病（10.2％）和当前吸烟率（14.4％）。左颈总动脉（CIMTLCCA）的平均CIMT和最大CIMT分别为0.56±0.10 mm和0.70±0.12 mm。他们的一年平均暴露量±标准偏差对于PM10为54.31±5.99μg/ m3，对于PM2.5为28.74±3.87μg/ m3，对于PM2.5 abs为2.14±0.36×10-5m-1。多元回归分析显示，平均CIMTLCCA平均百分数（95％置信区间）增加每5μg/ m3 PM2.5为2.51％（0.47-4.52％），每1.0×10-5m-1PM2为5.03％（0.60-9.47％）。每10μg/ m3 PM10分别为5 abs和2.69％（0.05-5.32％）。结论：以CIMT为代表的亚临床动脉粥样硬化与长期暴露于交通相关的PM2.5，PM2.5 abs，PM10对中年人呈正相关。

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