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首页> 外文会议>Annual conference of the International Society of Exposure Science >Exposure to Polyfluroaikyl Compounds in the Mid Ohio River Valley and Associations with Consumption of Ohio River Water
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Exposure to Polyfluroaikyl Compounds in the Mid Ohio River Valley and Associations with Consumption of Ohio River Water

机译：俄亥俄河中谷地区多氟烷基化合物的暴露以及与俄亥俄河水消费的关联

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Background: Polyfluroalkyl compounds (PFCs) are bioaccumulative; health effects may include impaired liver function, cholesterol metabolism, pubertal development and cancer. An industrial plant in Parkersburg, WV discharged PFCs into the Ohio River beginning in 1980; elevated PFCs were detected in Ohio River water samples in 2009. Communities immediately downstream of the Parkersburg plant and a cohort of girls in Cincinnati, OH have elevated serum PFOA. Aims: Determine serum PFC concentrations in the Ohio River Valley population and identify potential exposure modifiers. Methods: Participants were recruited around Huntington, WV, Portsmouth, OH and Cincinnati, OH from May 2009 to January 2012, and provided water consumption, health effects, and residential history data. Water sources were identified through records searches and meetings with utilities. Serum samples were analyzed for 11 PFCs. Associations between serum PFC and recruitment site, sex, age, sample collection time, drinking water source, water consumption and water filter use were analyzed using ANCOVA. Results: Participants (N=370) were 2-85 years old, 72% female and 96% Caucasian, and used the Ohio River/Ohio River Aquifer as a drinking water source from 0 to 30+ years. 96% of participants drank tap water; 87% drank some bottled water. PFHxS (median=1.4ng/mL), PFNA (median=1.2ng/mL), PFOA (median=8.1ng/mL) and PFOS (median=7.1ng/mL) were detected in ＞99% of participants; PFDeA and Me-PFOSA-AcOH (medians=0.2ng/mL) were detected in ＞50%. All site median values for PFOA serum concentration (Huntington=7.8ng/mL; Portsmouth=8.8ng/mL; Cincinnati=6.1ng/ml) were above the 2009-2010 NHANES 90th percentile. Preliminary analysis found a significant association between serum PFOA level and years of using the Ohio River as a water source. Conclusions: Ohio River Valley residents have elevated PFOA exposure, but not other PFCs, in line with other studies. These findings suggest a major component of PFOA exposure is drinking water from the Ohio River.
机译：背景：聚氟烷基化合物（PFC）具有生物蓄积性;健康影响可能包括肝功能受损，胆固醇代谢，青春期发育和癌症。西弗吉尼亚州帕克斯堡的一家工业工厂从1980年开始将PFC排放到俄亥俄河。 2009年，在俄亥俄河的水样中检测到PFC升高。帕克斯堡工厂下游的社区以及俄亥俄州辛辛那提的一群女孩血清PFOA升高。目的：确定俄亥俄州河谷人群的血清PFC浓度，并确定潜在的暴露修饰剂。方法：从2009年5月至2012年1月在西弗吉尼亚州亨廷顿市，俄亥俄州朴次茅斯市和俄亥俄州辛辛那提市附近招募参与者，并提供用水量，健康影响和居住历史数据。通过记录搜索和与公用事业公司会晤确定了水源。分析血清样品中的11种PFC。使用ANCOVA分析了血清PFC与募集部位，性别，年龄，样品采集时间，饮用水水源，水消耗和滤水器使用之间的关联。结果：参与者（N = 370）年龄在2至85岁之间，女性为72％，白种人为96％，并且使用了俄亥俄河/俄亥俄州河蓄水层作为0至30岁以上的饮用水源。 96％的参与者喝了自来水; 87％的人喝了一些瓶装水。在＞ 99％的参与者中检测到PFHxS（中位数= 1.4ng / mL），PFNA（中位数= 1.2ng / mL），PFOA（中位数= 8.1ng / mL）和PFOS（中位数= 7.1ng / mL）;检出的PFDeA和Me-PFOSA-AcOH（中位数= 0.2ng / mL）＞ 50％。 PFOA血清浓度的所有位点中位数值（亨廷顿= 7.8 ng / mL;朴次茅斯= 8.8 ng / mL;辛辛那提= 6.1 ng / mL）均高于2009-2010 NHANES的第90个百分点。初步分析发现，血清PFOA水平与使用俄亥俄河作为水源的年限之间存在显着相关性。结论：与其他研究一致，俄亥俄州河谷居民的PFOA暴露升高，但其他PFC则没有升高。这些发现表明，暴露于PFOA的主要成分是来自俄亥俄河的饮用水。

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