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首页> 外文会议>Annual conference of the International Society of Exposure Science >Winter Season Temperature Drops and Sulfur Dioxide Levels Affect on Exacerbation of Refractory Asthma in South Korea
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Winter Season Temperature Drops and Sulfur Dioxide Levels Affect on Exacerbation of Refractory Asthma in South Korea

机译：韩国冬季温度下降和二氧化硫水平对难治性哮喘恶化的影响

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Background. According to the American Thoracic Society, approximately 5% of all asthmatics have refractory asthma (RA); these patients fail to recover lost lung function even after long-term treatment with high doses of medications. Aims: We assessed the prevalence of RA and evaluated the association between acute exposure to ambient air pollution and meteorological conditions with acute exacerbation of RA after controlling for smoking and seasonality. Methods. Using a time-trend controlled case-crossover study design, we calculated odds ratios to evaluate whether exposure to ambient air pollutants and certain meteorological conditions on the day of admission (Lag 0) and up to 3 days before admission (Lagl through Lag 3) were associated with acute RA exacerbation. Results were obtained after controlling for the effects of seasonality, smoking, and allergen sensitivity; we stratified our data into four seasons with respect to the median temperature of each month and further stratified them according to self-reported smoking status and skin-prick test results. Results. In our study, RA patients (n = 82), living in metropolitan city of Seoul and Kyunggi Province, accounted for 3.7% of all asthmatics (n=2298) registered in our asthma cohort between 2005 and 2009. In winter, a 1_C decrease in ambient temperature and a 1 ppb increase in sulfur dioxide concentration on the day of Lag 1 were associated with 14.8% (95% confidence interval [CI]: 0.9-26.7) and 19.7% (95% CI: 3.3-38.7) increases in the risk of RA exacerbation among nonsmokers, respectively. Similar associations were obtained on the day of Lag 2. The association remained unchanged after excluding patients sensitive to Dermatophagoides farinae and Dermatophagoides pteronyssinus. Conclusions. Exposure to temperature drops and increased sulfur dioxide concentrations are positively associated with the occurrence of acute RA exacerbation during winter with 1 or 2 day lags.
机译：背景。根据美国胸科协会的统计，所有哮喘患者中约有5％患有难治性哮喘（RA）。这些患者即使长期接受大剂量药物治疗也无法恢复失去的肺功能。目的：我们评估了RA的流行程度，并评估了控制吸烟和季节性后急性暴露于环境空气污染与气象条件与RA急性加重之间的关系。方法。使用时间趋势控制的案例交叉研究设计，我们计算了优势比，以评估入院当天（滞后0）和入院前3天（滞后至滞后3）是否暴露于环境空气污染物和某些气象条件与急性RA加重有关。在控制季节性，吸烟和过敏原敏感性的影响后获得结果;我们根据每个月的中位数温度将数据分为四个季节，并根据自我报告的吸烟状况和皮肤点刺试验结果进一步对数据进行分层。结果。在我们的研究中，居住在大城市首尔和京畿道的RA患者（n = 82）占2005年至2009年间在我们的哮喘队列中注册的所有哮喘患者（n = 2298）的3.7％。冬季，患者的C下降了1_C在滞后1天，环境温度的升高和二氧化硫浓度的增加1 ppb与14.8％（95％置信区间[CI]：0.9-26.7）和19.7％（95％CI：3.3-38.7）相关非吸烟者患RA恶化的风险。在滞后2天获得了类似的关联。在排除对法氏皮肤癣菌和翼龙皮肤过敏症敏感的患者后，该关联保持不变。结论暴露于温度下降和增加的二氧化硫浓度与冬季有1或2天滞后的急性RA加重呈正相关。

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