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首页> 外文会议>Annual conference of the International Society of Exposure Science >Prenatal Bisphenol A Urine Concentrations and Early Rapid Growth and Overweight Risk in the First Years of Life
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Prenatal Bisphenol A Urine Concentrations and Early Rapid Growth and Overweight Risk in the First Years of Life

机译：出生后第一年的产前双酚A尿浓度，早期快速生长和超重风险

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Background: Increasing experimental evidence suggests that developmental exposure to bisphenol A (BPA) increases offspring weight gain later in life. However, this hypothesis has not yet been explored in prospective cohort studies. Aim: We examined the effects of maternal BPA exposure during pregnancy on rapid growth in the first 6 months of life and subsequent body mass index (BMI) and waist circumference at the ages of 14 months and 4 years. Methods: BPA concentrations were measured in two spot urine samples collected in the 1st and 3rd trimesters of pregnancy from mothers of the Spanish INMA birth cohort study (N=402). The average of the two creatinine-adjusted BPA concentrations was used as exposure variable. Rapid growth was defined as a weight gain z-score ＞ 0.67 in the first 6 months of life. Child age-and-sex specific BMI z-scores were calculated at age 14 months and 4 years based on the WHO referent; overweight was defined as a BMI z-score ≥ the 85th percentile. Age-and-sex-specific waist circumference z-scores were calculated at age 14 months and 4 years using the analysis population mean. Results: Twenty-six percent of infants were rapid growers, 26% were overweight at 14 months and 21% at 4 years. BPA concentrations (GM+GSD) were 2.6 ± 2.3 in 1st and 2.0 ± 2.3 μg/g creatinine in 3rd trimester samples (Pearson r=0.13, p＜0.01). At 4 years, associations were observed between BPA exposure and increased waist circumference (β z-score per log10 μg/g: 0.29; 95% CI: 0.01, 0.58) and BMI (β z-score: 0.27; 95%CI: -0.08, 0.62). BPA was not related to the obesity-related outcomes assessed at earlier ages. Conclusions: Findings suggest an association between BPA exposure and obesity-related outcomes in childhood, but not earlier in infancy. The short half-life and large within-person variability of BPA exposure create uncertainties in exposure assessment which may have biased results towards the null hypothesis.
机译：背景：越来越多的实验证据表明，发育暴露于双酚A（BPA）会增加后代的后代体重增加。但是，该假说尚未在前瞻性队列研究中进行探讨。目的：我们检查了孕期孕产妇接受BPA对出生后头6个月的快速生长以及随后的14个月和4岁时的体重指数（BMI）和腰围的影响。方法：从西班牙INMA出生队列研究的母亲（N = 402）在怀孕的第1和第3孕中期收集的两个尿样中测量BPA浓度。肌酐调整后的两个BPA浓度的平均值用作暴露变量。快速增长被定义为生命的头6个月体重增加z分数> 0.67。根据WHO参考资料，分别计算了14个月和4岁儿童的年龄和性别特定的BMI z得分;超重定义为BMI z分数≥85个百分点。使用分析总体平均值，在14个月和4岁时计算出特定于年龄和性别的腰围z分数。结果：26％的婴儿是快速成长的婴儿，26％的婴儿在14个月时超重，21％的4岁时超重。第一个三个月的样本中BPA浓度（GM + GSD）为2.6±2.3，三个月的肌酐为2.0±2.3μg/ g（Pearson r = 0.13，p ＜0.01）。在4年时，观察到BPA暴露与腰围增加（每log10μg/ gβz分数：0.29; 95％CI：0.01，0.58）和BMI（βz分数：0.27; 95％CI：- 0.08，0.62）。 BPA与早期评估的肥胖相关结果无关。结论：研究结果表明，BPA暴露与儿童肥胖相关结局之间存在关联，但在婴儿早期并不如此。 BPA暴露的半衰期短且人际变异大，这在暴露评估中造成了不确定性，这可能会使结果偏向无效假设。

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