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首页> 外文会议> >PRESENCE OF THE ALA ALLELE IN THE PPAR-GAMMA GENE IS NOT PROTECTIVE AGAINST RISK OF IMPAIRED GLUCOSE METABOLISM ASSOCIATED WITH POP EXPOSURE
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PRESENCE OF THE ALA ALLELE IN THE PPAR-GAMMA GENE IS NOT PROTECTIVE AGAINST RISK OF IMPAIRED GLUCOSE METABOLISM ASSOCIATED WITH POP EXPOSURE

机译：PPAR-伽马基因中存在AAL等位基因不能预防与POP暴露相关的糖代谢异常的风险

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Background Exposure to persistent organic pollutants (POPs) is associated with type 2 diabetes. Presence of the Ala allele in the peroxisome proliferator-activated receptor-gamma (PPARG) gene has been shown to be protective against type 2 diabetes, due to decreased accumulation of adipose mass. AIMS The objective is to study whether the presence of the Ala allele is protective against increased risk of type 2 diabetes associated with POP exposure among Finnish elderly subjects.METHODS The original birth cohort consists of 8,760 people born as singletons at the Helsinki University Central Hospital during 1934-1944. From the original study cohort, 2,003 men and women were selected at random to attend a clinical examination in 2003. The examination included a standard 2-h 75-g oral glucose tolerance test (0, 30 and 120 min), and blood sampling. WHO 2009 diagnostic criteria for type 2 diabetes and glucose regulation were used. Regression analyses were adjusted for age, sex, and waist circumference. The serum concentrations of oxychlordane, trans-nonachlor, p,p′-DDE, and PCB 153 were transformed into normalized ranks, summed, and categorized using 25th and 75th percentiles as cutoff points.RESULTS The frequency of Ala allele was 18% and the median serum concentrations of oxychlordane, trans-nonachlor, p,p′-DDE, and PCB 153 were 11, 28, 470, and 287 pg/g of lipid, respectively. High POP exposure was positively associated with type 2 diabetes, among both carriers with (OR=2.8, p=0.003) and without (OR=1.7, p=0.025) the Ala allele. However, POP exposure was associated with impaired fasting glucose among carriers (OR=2.8, p=0.002), whereas among non-carriers the association was inverse but non-significant (OR=0.38, p=0.14). POP exposure was not associated with glucose secretion, but significantly decreased insulin secretion during OGTT regardless of PPARG genotype.CONCLUSIONS Association between POPs and type 2 diabetes and early signs of impaired glucose metabolism is irrespective of PPARG polymorphism.
机译：背景持久性有机污染物（POPs）的暴露与2型糖尿病有关。由于脂肪堆积的减少，过氧化物酶体增殖物激活的受体-γ（PPARG）基因中Ala等位基因的存在已被证明可抵抗2型糖尿病。目的目的研究芬兰老年人中Ala等位基因的存在是否可以防止与POP暴露相关的2型糖尿病风险的增加。方法最初的出生队列由8,760例在赫尔辛基大学中心医院出生的人组成。 1934-1944年。从最初的研究队列中，2003年随机选择了2003名男性和女性参加临床检查。检查包括标准的2小时75克口服葡萄糖耐量测试（0、30和120分钟）和血液采样。使用了WHO 2009年用于2型糖尿病和葡萄糖调节的诊断标准。对年龄，性别和腰围进行回归分析调整。用第25和第75个百分位数作为截断点，将氧氯丹，反式壬草胺，p，p'-DDE和PCB 153的血清浓度转换为归一化等级，求和并分类。结果Ala等位基因的频率为18％，血氯丹，反式六氯胺，p，p'-DDE和PCB 153的中值血脂分别为11、28、470和287 pg / g脂质。在具有（OR = 2.8，p = 0.003）和没有（OR = 1.7，p = 0.025）Ala等位基因的两种携带者中，高POP暴露与2型糖尿病呈正相关。但是，POP暴露与携带者之间的空腹血糖受损有关（OR = 2.8，p = 0.002），而在非携带者之间，该关联是相反的但无统计学意义（OR = 0.38，p = 0.14）。 POP暴露与葡萄糖分泌无关，但无论PPARG基因型如何，OGTT期间胰岛素分泌均显着降低。结论POPs与2型糖尿病和葡萄糖代谢受损的早期迹象之间的关联与PPARG多态性无关。

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