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首页> 外文会议>Annual conference of the International Society of Exposure Science >Understanding the endocrine disruption potential of hazardous chemicals in children's products and their proposed alternatives using in vitro data
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Understanding the endocrine disruption potential of hazardous chemicals in children's products and their proposed alternatives using in vitro data

机译：了解儿童产品的危险化学品的内分泌破坏潜力及其在体外数据的拟议替代品

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Children's consumer products represent an important exposure source for many toxicants due to their intended uses, which lead to direct contact with children. Examples of chemicals found in children's products include phthalates, bisphenols and parabens. As regulation and reporting requirements increase, demand for safer alternatives to these chemicals has also increased. Alternatives assessments are used to identify safer chemical alternatives, however, many times these assessments are limited by lack of toxicity data. This biases the alternatives assessment to conclude that the new chemical is safer, when in fact it may be just less well studied. This project examines how in vitro data can fill gaps in alternatives assessments for hazardous chemicals found in children's consumer products. Formal national and international lists, such as the European Chemical Agency's (ECHA) Endocrine Disruptor Substances of Concern classification are compared with the toxicological prioritization index (ToxPi) score calculated based on the United Stated Environmental Protection Agency's ToxCast Database. Formal lists are primarily derived using data from human and animal studies, and the ToxPi score is based on in vitro assay results. Three chemical groups were considered: phthalates, parabens and bisphenols. Though alternative chemicals were rarely classified as endocrine disruptors by the ECHA, the in vitro ToxPi scores for alterative chemicals were slightly higher for bisphenols and phthalates. The results from this case study suggest that in vitro data can help fill gaps when existing classifications are incomplete. This project is supported by the Environmental Protection Agency (FP-91779601-0, RD 83573801, RD 83451401) and the National Institute of Environmental Health Sciences (5P01ES009601).
机译：由于其预期用途，儿童消费产品代表了许多毒物的重要曝光源，这导致与儿童直接接触。儿童产品中发现的化学物质的实例包括邻苯二甲酸盐，双酚和羟基苯甲酸酯。随着规范和报告要求的增加，对这些化学品的更安全的替代品也增加了。替代方案评估用于识别更安全的化学替代品，然而，这些评估的许多次数受到毒性数据的限制。这一偏见了替代评估，以得出结论，新化学品更安全，实际上它可能不太清晰。该项目研究了在儿童消费产品中发现的危险化学品评估中的体外数据如何填补空白。与欧洲化学机构（ECHA）内分泌破坏物质的正式国家和国际名单相比，涉及涉及的毒理学优先级指数（TOXPI）得分，根据联合国环境保护局的Toxcast数据库计算。正式列表主要是使用来自人和动物研究的数据来源的，并且ToxPI评分基于体外测定结果。考虑了三个化学基团：邻苯二甲酸酯，羟基苯甲酸酯和双酚。尽管替代化学品很少被ECHA被归类为内分泌破坏剂，但对于双酚和邻苯二甲酸盐略高于替代化学品的体外TOXPI评分。本例研究的结果表明，当现有分类不完整时，体外数据可以帮助填补间隙。该项目由环境保护局（FP-91779601-0，RD 83573801，RD 83451401）和国家环境卫生研究所（5P01ES009601）提供支持。

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