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首页> 外文会议>Annual conference of the International Society of Exposure Science >Possible association of prenatal exposure to endocrine disruptors with sex-typical development and autism traits - Results from the Duisburg birth cohort study
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Possible association of prenatal exposure to endocrine disruptors with sex-typical development and autism traits - Results from the Duisburg birth cohort study

机译：具有性典型发展和自闭症性状的内分泌破坏者的产前暴露的可能协会 - 杜伊斯堡出生队列研究结果

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Background: Polychlorinated biphenyls (PCB), dibenzo-p-dioxins and dibenzofurans (PCDD/F) are characterized as endocrine disrupters (ED) that assumedly influence steroid hormones. During pregnancy brain development depends on hormones, especially fetal testosterone (fT) which plays a crucial role for the male-typical brain differentiation. Studies have found relations between fT and empathy, analytical thinking and sex-typical play behaviour. The causes of autism spectrum conditions (ASC) are yet unclear, however some researchers see them as an extreme form of the male brain. ED might influence fT which in turn might influence sex-typical behaviour and autistic traits. Aims: Within the Duisburg birth cohort study we investigated the effects of prenatal exposure to PCB and PCDD/F on sex-typical behaviour and autism traits. Methods: WHO2005-TEqs of PCB and PCDD/F (pg/g lipid base) in maternal blood were used as a measure for exposure. At 8-10 years of age the mothers of 97 children (52 boys) filled out the "Empathy-Systemizing-Quotient" (EQ-SQ), assessing sex-typical cognition. At 9-11 years of age the mothers of 102 children (54 boys) completed the "Social Responsiveness Scale" (SRS), an autism rating scale. Results: Exposure to PCB and PCDD/F was within background levels (e.g. medianPCB = 6.85 ± 3.88). We found negative correlations between PCB levels and the EQ (rs = -.320, p ＜ .05) in girls and negative correlations between PCDD/F levels and the SQ (rs = -.330, p ＜ .05) in boys. The SRS was inversely related to PCDD/F levels (rs = -.301) and PCB levels (rs = -.265, all p ＜ .01). When analyzed separately, correlations were no longer significant in boys but in girls. Conclusions: We found significant associations of prenatal background exposure to PCB and PCDD/F with sex-typical behaviour and autistic traits. The causes of ASC are still unknown, however it is assumed that they are multifactorial and environmental factors such as ED that alter fetal steroid hormone levels might be an important factor.
机译：背景：多氯联苯（PCB），二苯甲酸二恶蛋白和二苯并呋喃（PCDD / F）的特征在于，内分泌破坏剂（ED），旨在影响类固醇激素。在怀孕期间，脑发育取决于激素，尤其是胎儿睾酮（FT），这对雄性典型的脑分化起着至关重要的作用。研究发现了FT和同理心，分析思维和性别典型的游戏行为之间的关系。自闭症谱条件（ASC）的原因尚不清楚，然而一些研究人员认为它们是雄性大脑的极端形式。 ED可能影响FT，这又可能影响性别典型的行为和自闭症特征。目的：在杜伊斯堡出生队列中，研究我们研究了产前暴露于PCB和PCDD / F对性别典型行为和自闭症特征的影响。方法：母体血液中PCB和PCDD / F（PG / G脂质碱）的WHO2005-TEQ作为暴露的措施。在8-10岁的时候，97名儿童（52个男孩）填写了“同理化系统化 - 额字”（EQ-SQ），评估性别典型的认知。 102名儿童（54个男孩）的母亲在9-11岁时完成了“社会响应量表”（SRS），自闭症评级规模。结果：接触PCB和PCDD / F在后台水平内（例如，MEDIANPCB = 6.85±3.88）。我们发现PCB级别与男孩/级和SQ（Rs = -.330，P <.05）之间的eq（rs = -.320，p <.05）之间的负相关性。 SRS与PCDD / F级别（RS = -.301）和PCB级别相反（Rs = -.265，所有P <.01）。在分开分析时，男孩虽然在男孩中，但在女孩中不再重要。结论：我们发现产前背景暴露于PCB和PCDD / F的重要关联，性别典型的行为和自闭症特征。 ASC的原因仍然是未知的，然而假设它们是多因素和环境因素，例如Alter胎儿类固醇激素水平可能是一个重要因素。

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