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首页> 外文会议>Annual conference of the International Society of Exposure Science >Hair Ionomic Profiles and Associations with Obesity Indicators from a Cypriot Young Adult Mate Cohort
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Hair Ionomic Profiles and Associations with Obesity Indicators from a Cypriot Young Adult Mate Cohort

机译：塞浦路斯年轻成年伴侣队列的头发经济学特征和与肥胖指标的关联

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Obesity is recognized as an important metabolic risk factor for a plethora of chronic diseases, including diabetes mellitus and cardiovascular diseases. Obese people are likely at a higher risk of developing deficiency for elemental nutrients such as magnesium, and/or having excess of certain toxic trace elements such as copper. Hair is a unique biological matrix that provides retrospective snapshot of environmental/dietary exposures. We hypothesized that perturbation in hair ion profiles serve as pre-stage indicators of obesity onset. This study aimed at exploring associations of trace elements and essential macronutrients profiles in hair with clinical and dietary measurements of obese people compared to healthy controls. Archived hair samples from the Cyprus Metabolism Prospective Cohort Study on young adult male sub-population was randomly selected for (ⅰ) normal weight (n=50), (ⅱ) overweight (n=50), and (ⅲ) obese (n=50) participants with BMI of ＜25, 25-30, and ＞30 kg m-2, respectively. Inductively coupled plasma mass spectrometry was used for high throughput profiling of 20 trace, toxic, and essential elements: antimony, arsenic, barium, calcium, cadmium, chromium, cobalt, copper, iron, lead, magnesium, manganese, mercury, molybdenum, nickel, potassium, selenium, sodium, vanadium, and zinc. Univariate and multivariate logistic regression analyses will be performed to evaluate associations between hair ionomic profiles and obesity indicators such as (ⅰ) adiposity measures (e.g. body mass index, waist-to-hip ratio), (ⅱ) metabolic risk indicators (e.g. cholesterol, metabolic syndrome), (ⅲ) biochemical markers (e.g. leptin-binding protein, triglycerides), and ⅳ) questionnaire-based self-reported dietary habits. Information on how obese and normal individuals differ in terms of hair elemental composition may help to understand their role as a cause or effect of obesity. Further insight on links between obesogen elemental mixtures and endocrine disruptors (such as zinc, cadmium, mercury) may be possible.
机译：肥胖被认为是许多慢性疾病（包括糖尿病和心血管疾病）的重要代谢危险因素。肥胖的人更有可能缺乏诸如镁的元素营养，和/或具有过量的某些有毒微量元素（例如铜）。头发是独特的生物基质，可提供环境/饮食暴露的回顾性快照。我们假设毛发离子概况中的摄动是肥胖发作的前期指标。这项研究旨在探索与健康对照相比，肥胖者的头发中的微量元素和必需的大量营养素概况与临床和饮食测量值之间的关联。来自塞浦路斯新陈代谢前瞻性研究的塞浦路斯头发样本是根据（ⅰ）正常体重（n = 50），（ⅱ）超重（n = 50）和（ⅲ）肥胖（n = 50）BMI分别＜25、25-30和> 30 kg m-2的参与者。电感耦合等离子体质谱仪用于高通量分析20种痕量，有毒和重要元素：锑，砷，钡，钙，镉，铬，钴，铜，铁，铅，镁，锰，汞，钼，镍，钾，硒，钠，钒和锌。将进行单因素和多因素logistic回归分析，以评估头发的肌群特征与肥胖指标之间的关联，这些指标包括（ⅰ）肥胖测量指标（例如，体重指数，腰臀比），（ⅱ）代谢风险指标（例如，胆固醇，代谢综合征），（ⅲ）生化指标（例如瘦素结合蛋白，甘油三酸酯）和（ⅳ）基于问卷的自我报告的饮食习惯。有关肥胖和正常人在头发元素组成方面的差异的信息可能有助于了解他们作为肥胖原因或后果的作用。关于肥胖原元素混合物与内分泌干扰物（例如锌，镉，汞）之间的联系的进一步见解是可能的。

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