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首页> 外文会议>Annual conference of the International Society of Exposure Science >Job Exposure Matrix (JEM) derived estimates of life-time occupational pesticide exposure and the risk of Parkinson's Disease
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Job Exposure Matrix (JEM) derived estimates of life-time occupational pesticide exposure and the risk of Parkinson's Disease

机译：作业暴露矩阵（JEM）得出了终身职业农药暴露和帕金森氏病风险的估计值

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Background: Previous studies repeatedly suggested that Parkinson's disease (PD) is associated with occupational pesticide exposure, but in many studies exposures were self-reported and none adjusted for concomitant ambient pesticide exposures. Objective: To investigate whether occupational exposure to pesticides increases the risk of PD in California's heavily agricultural region. Methods: We enrolled 357 incident PD cases and 750 population controls in a case-control study in California's Central Valley between 2001 to 2011. A comprehensive Job Exposure Matrix (JEM) was developed to assess participant's life-time cumulative occupational pesticide exposure based on work history and detailed job tasks information. Results: PD risk was estimated to be more than 2-fold higher (OR=2.19 95%CI 1.26, 3.82) in men who were classified as highly occupational exposed with our data suggesting an exposure-response (trend p=0.007). Farming tasks with more direct and intense pesticide exposures such as applying, spraying and mixing of pesticides resulted in greater risks than indirect exposures from general tasks such as planting, harvesting, packing, sorting, etc. Results did not change when we adjusted for residential and occupational ambient pesticide exposures estimated based on a Geographic Information System (GIS) model. Conclusion: We provide further evidence that occupational pesticide exposure increases the risk of PD in men and ambient exposures did not confound these associations.
机译：背景：先前的研究反复表明帕金森氏病（PD）与职业性农药接触有关，但是在许多研究中，暴露是自我报告的，并且没有针对伴随的环境农药暴露进行调整。目的：调查在加利福尼亚的农业密集地区，职业性接触农药是否会增加PD的风险。方法：在2001年至2011年间，我们在加利福尼亚中央谷地的病例对照研究中纳入了357例PD事件和750例人口对照。建立了一个全面的工作暴露矩阵（JEM），用于根据工作评估参与者的终生累积职业性农药暴露量历史记录和详细的工作任务信息。结果：根据我们的数据显示暴露-反应（趋势p = 0.007），估计被分类为高职业暴露的男性的PD风险高出2倍以上（OR = 2.19 95％CI 1.26，3.82）。与直接，强烈地接触农药（例如施用，喷洒和混合农药）的耕作任务相比，从一般任务（例如种植，收割，包装，分类等）中间接暴露出的风险更大。根据地理信息系统（GIS）模型估算的职业环境农药暴露量。结论：我们提供了进一步的证据，表明职业性农药暴露增加了男性发生PD的风险，而环境暴露并未混淆这些关联。

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