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首页> 外文会议>Annual conference of the International Society of Exposure Science >Oxidative Stress Biomarkers in Residents 4 years After the Hebei Spirit Oil Spill
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Oxidative Stress Biomarkers in Residents 4 years After the Hebei Spirit Oil Spill

机译：河北精神溢油事故发生四年后居民的氧化应激生物标志物

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Background: We found a dose-response relationship between the severity of exposure to spilled crude oil and oxidative stress biomarkers even 1.5 years after the Hebei Spirit oil spill accident occurred in December 2007. Follow-up oxidative stress biomarker studies were undertaken approximately 3 years and 4 years after the accident in residents who live in highly exposed areas. Aims: This study was to assess the possible long-term persistence and recovery associated with the exposure to complex mixtures of spilled crude oil. Methods: Residents qualified for the follow-up studies were those whose residence is located within 8 km from the early contaminated coastline among the baseline cohort population. A total of 161 participants were enrolled at three times in February to April, 2009, October to November, 2010, and February to March, 2012. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and urinary malondialdehyde (MDA) levels were measured as indicators of oxidative DNA damage and lipid peroxidation, respectively. Results: The geometric mean of urinary 8-OHdG and MDA levels, 1.5 years, 3 years, and 4 years after the disasters were 6.0, 6.3, and 6.7 μg/g creatinine (cr) and 3.5, 2.6, 2.5 μmol/g cr, respectively. The urinary 8-OHdG levels had slightly increased as time passed in highly affected group, but the oxidative stress biomarkers did not correlate with the clean-up work duration and the distance indicators any longer adjusting for potential covariates 3 years and 4 years after the Hebei Spirit oil spill. Conclusions: Although time passed, the urinary 8-OHdG levels hardly changed during the follow-up period. Increased 8-OHdG levels might be related to the emergence of chronic progressive diseases, such as respiratory, allergic inflammatory, obesity, diabetes, atherosclerosis, and cancer.
机译：背景：即使在2007年12月发生的河北精神石油泄漏事故发生1.5年后，我们也发现泄漏的原油暴露的严重程度与氧化应激生物标志物之间存在剂量反应关系。对氧化应激生物标志物进行了约3年的随访研究，事故发生后的4年内，居住在高暴露地区的居民。目的：本研究旨在评估与溢油原油的复杂混合物接触可能产生的长期持久性和恢复性。方法：符合随访研究条件的居民是居住在基线人群中距早期受污染海岸线8公里以内的居民。在2009年2月至2009年4月，2010年10月至11月和2012年2月至2012年3月共分三期招募了161名参与者。尿液中的8-羟基-2'-脱氧鸟苷（8-OHdG）和尿液中的丙二醛（MDA）测定其水平分别作为氧化DNA损伤和脂质过氧化的指标。结果：灾后1.5年，3年和4年尿液中8-OHdG和MDA的几何平均值分别为6.0、6.3和6.7μg/ g肌酐（cr）和3.5、2.6、2.5μmol/ g cr ， 分别。随着时间的流逝，高度受影响的人群尿中的8-OHdG水平略有增加，但氧化应激生物标志物与清理工作的持续时间无关，距离指标不再适应河北省3年和4年后的潜在协变量。烈性石油泄漏。结论：尽管时间流逝，但在随访期间尿中的8-OHdG水平几乎没有变化。 8-OHdG水平升高可能与诸如呼吸道，过敏性炎症，肥胖，糖尿病，动脉粥样硬化和癌症等慢性进行性疾病的出现有关。

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