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首页> 外文会议>Annual conference of the International Society of Exposure Science >Early life Exposure to Environmental Tobacco Exposure and Atherogenesis
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Early life Exposure to Environmental Tobacco Exposure and Atherogenesis

机译：生命早期暴露于环境烟草暴露和致热作用

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Background: Early exposure to environmental tobacco smoke (ETS) is associated with adverse health outcomes in children and adolescents: reduced lung function growth, asthma and adverse birth outcomes. Less is known on the impact of early life ETS exposure on cardiovascular health and atherosclerosis, although ETS is considered to be highly atherogenic in adults and remains a prevalent exposure in utero and childhood. Aim: 1. Present the state of knowledge on early life/childhood risk factors for atherogenesis, focusing on early life ETS exposure. 2. Present complexity and challenges in investigating early life origins of health and disease 3. and the SAPALDIA Youth Study designed to study early life factors of atherosclerosis. Results: Atherosclerosis is a multi-factorial disease with origins in childhood and in utero. Metabolic and morphologic alterations may result from ETS with toxic compounds crossing the placenta barrier and vaso-constrictive agents reducing the blood flow to the fetus. Childhood ETS exposure has been associated with cardiovascular risk factors: obesity,metabolic syndrome,leptin, adinopectin, CRP, oxidative stress. Studies on ETS and functional or structural changes of the vasculature in children are few. The challenge in research on early life origins of disease lies in the disparity of timing of exposure and disease manifestation. Developmental plasticity and adaptive responses of the human organism add to the complexity. The SAPALDIA Youth Study, the first Swiss offspring study, is designed to study early life factors and cardiovascular health, with a focus on atherosclerosis, addressing vulnerable time windows. Conclusion: ETS exposure in childhood is a risk factor for atherogenesis in adults and children. Considerable evidence supports the early life impact of ETS exposure on children's cardiovascular risk profile. First findings pointing to functional and structural changes to the vasculature in children need affirmation. The SAPALDIA Youth Study can bridge the time windows of early exposure and later disease manifestation.
机译：背景：早期接触环境烟草烟雾（ETS）与儿童和青少年的不良健康后果相关：肺功能增长降低，哮喘和不良的出生后果。尽管ETS被认为在成年人中具有很高的动脉粥样硬化性，并且在子宫和儿童中仍很普遍，但人们对早期ETS暴露对心血管健康和动脉粥样硬化的影响知之甚少。目标：1.介绍有关动脉粥样硬化的生命早期/儿童危险因素的知识状态，重点是生命早期ETS暴露。 2.在研究健康和疾病的早期生命起源方面的复杂性和挑战3.以及旨在研究动脉粥样硬化的早期生命因素的SAPALDIA青年研究。结果：动脉粥样硬化是一种多因素疾病，起源于儿童期和子宫内。 ETS可能会引起代谢和形态学改变，其中有毒化合物会穿过胎盘屏障，而血管收缩剂则会减少流向胎儿的血液。儿童ETS暴露已与心血管危险因素相关：肥胖，代谢综合征，瘦素，脂联素，CRP，氧化应激。对儿童的ETS和血管系统功能或结构变化的研究很少。在疾病的早期生命起源研究中，挑战在于暴露时间和疾病表现的时间差异。人类有机体的发育可塑性和适应性反应增加了复杂性。 SAPALDIA青年研究是瑞士的第一项后代研究，旨在研究早期生活因素和心血管健康，重点是动脉粥样硬化，解决脆弱的时间窗口。结论：儿童时期的ETS暴露是成人和儿童发生动脉粥样硬化的危险因素。大量证据支持ETS暴露对儿童心血管风险的早期影响。指出儿童脉管系统功能和结构变化的初步发现需要肯定。 SAPALDIA青年研究可以弥合早期接触和后期疾病表现的时间窗口。

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