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首页> 外文会议>Annual conference of the International Society of Exposure Science >Looking back to move forward: Lessons learned from the RESPIRE trial applied to the NACER study
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Looking back to move forward: Lessons learned from the RESPIRE trial applied to the NACER study

机译：回顾前进：从RESPIRE试验获得的经验教训已应用于NACER研究

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Background: Few studies have examined the association between household air pollution (HAP) and low birth weight (LBW). Only one study directly measured prenatal carbon monoxide exposures among women enrolled in the RESPIRE randomized stove intervention trial. Aims:The NACER pilot study builds off our earlier experience and aims to: 1) measure personal exposures to carbon monoxide (CO), particulate matter (PM2.5) and polycyclic aromatic hydrocarbons (PAHs) during pregnancy and the first year of infant life; and 2) collect standardized measures of infant weight, length and head circumference, newborn gestational age and infant neurodevelopment. Methods: Guatemalan, indigenous women were recruited through a rural Ministry of Health clinic at ＜ 20 weeks gestation and received prenatal health exams at ＜ 20, 24-28, and 32-36 weeks. Home visits were made 3 times during pregnancy to monitor prenatal HAP. Home visits were made within 48 hours of birth and at 1, 3, 6, 9, and 12 months to assess infant anthropometry and neurodevelopment using a validated 27-item instrument (Rapid Neurodevelopmental Assessment (RNDA)). Personal CO and PM exposures were measured using real time monitors and 5 gas-phase PAHs were measured using passive diffusion badges worn over a 48-hour period. Results: 37 pregnant women were enrolled. Gestational age was confirmed by fetal ultrasound (mean: 15.2 weeks, range 7-20.1). Eleven percent of households used open fires for cooking; 89% used deteriorated vented chimney stoves. Maternal and neonatal exposures to CO, PM2.5 and PAHs will be presented. 29% of infants were low birth weight (＜ 2,500 grams) and 6% were preterm (＜ 37 weeks). Among neonates, moderate/severe neurodevelopmental impairment were: fine motor (13%), gross motor (32%), speech (16%), cognition (32%), behavior (13%), vision (45%), hearing (39%), primitive reflexes (23%), and seizures (0). Conclusions: Maternal PM and CO exposures were significantly greater than neonatal exposures. LBW and moderate/severe neurodevelopmental impairment were both high. In a future, larger study we will measure the impact of maternal and neonatal HAP exposures on LBW, preterm delivery and infant neurodevelopmental impairment.
机译：背景：很少有研究检查家庭空气污染（HAP）与低出生体重（LBW）之间的关联。只有一项研究直接测量了RESPIRE随机炉灶干预试验的妇女的产前一氧化碳暴露量。目的：NACER试点研究建立在我们较早的经验基础上，旨在：1）在怀孕和婴儿出生的第一年中，测量个人对一氧化碳（CO），颗粒物（PM2.5）和多环芳烃（PAHs）的暴露量; 2）收集婴儿体重，身长和头围，新生儿胎龄和婴儿神经发育的标准化指标。方法：危地马拉的土著妇女在妊娠＜20周时通过农村卫生部诊所招募，并在＜20、24-28和32-36周接受产前健康检查。怀孕期间进行了3次家访，以监测产前HAP。在出生后48小时内，1、3、6、9和12个月内进行家访，以使用经过验证的27个项目的仪器（快速神经发育评估（RNDA））评估婴儿的人体测量学和神经发育。使用实时监控器测量个人的CO和PM暴露，并使用48小时内佩戴的被动扩散标志测量5个气相PAH。结果：37名孕妇入选。胎儿超声检查证实了胎龄（平均：15.2周，范围7-20.1）。 11％的家庭使用明火做饭; 89％的人使用了老化的排气烟囱炉。将介绍孕妇和新生儿接触CO，PM2.5和PAHs的情况。 29％的婴儿为低出生体重（＜2500克），6％为早产（＜37周）。在新生儿中，中度/重度神经发育障碍为：精细运动（13％），大运动（32％），言语（16％），认知（32％），行为（13％），视力（45％），听力（ 39％），原始反射（23％）和癫痫发作（0）。结论：孕妇的PM和CO暴露量显着高于新生儿。 LBW和中度/重度神经发育障碍均很高。在未来的大型研究中，我们将评估母体和新生儿HAP暴露对LBW，早产和婴儿神经发育障碍的影响。

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