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首页> 外文会议>Annual conference of the International Society of Exposure Science >Urinary bisphenol A levels and increasing body mass: results of a cross-sectional study
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Urinary bisphenol A levels and increasing body mass: results of a cross-sectional study

机译：尿中双酚A水平和体重增加：一项横断面研究结果

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Background According to the WHO, over 700 million obese people there are in the world and about 2 billion people are overweight. BPA has been shown to have endocrine-disrupting effects like behavioral changes, altered growth, and early secondary sexual maturation. In particular, there is evidence that epigenetic changes associated with the use of manmade chemicals may interact with other factors that influence fetal and postnatal growth in contributing to the current obesity epidemic. Epidemiological data in humans are still lacking. Aims A possible association between the urinary BPA levels and body mass index (BMI) of general adult population of the south Italy was investigate. Methods Occupation, education, and lifestyle habits, such as tobacco smoking, alcohol consumption, and other common demographic data were collected by a specific questionnaire. Overweight was defined as BMI from 25 to less than 29.9 kg/m2 and obesity was defined as BMI ＞30 kg/m2. Pooled 24 h urine samples were collected in polyethylene con-tainers and stored at-20°C until the analysis. BPA was determined by HPLC/MS. Results Participants were adults (61% females) non occupational exposed to BPA with the mean age of 50±13.6 years. 5.6% of the subjects were underweight, 33.3% were normal weight, 55.6% were overweight and 5.6% were obese. Average levels of urinary BPA show a trend from underweight to overweight subjects. The same trend is highlighted both for males and females group. A trend is not highlighted for obese group probably because of the small sample size. Conclusions Our results confirm the link between BPA exposure and the increased body mass as well as a widespread BPA exposure which might be an important risk factor for body weigh increase. Therefore, is recommended the counseling of patients by health professionals to decrease levels of exposure to endocrine disruptors particularly during important periods of development such as pregnancy, infancy and puberty.
机译：背景根据世界卫生组织的资料，全世界有7亿肥胖者，超重者约20亿。 BPA已显示具有破坏内分泌的作用，例如行为改变，生长改变和早期继发性成熟。特别是，有证据表明，与使用人造化学物质有关的表观遗传学变化可能与影响胎儿和产后生长的其他因素相互作用，从而加剧了当前的肥胖病流行。人类的流行病学数据仍然缺乏。目的研究意大利南部普通成年人的尿液BPA水平与体重指数（BMI）之间的可能联系。方法通过特定的问卷调查收集职业，教育和生活方式习惯，例如吸烟，饮酒和其他常见的人口统计数据。超重定义为BMI从25降至29.9 kg / m2以下，肥胖定义为BMI＞ 30 kg / m2。将收集的24小时尿液样本收集在聚乙烯容器中，并保存在20°C下直至分析。 BPA通过HPLC / MS测定。结果参与者为非职业性接触BPA的成年人（61％的女性），平均年龄为50±13.6岁。 5.6％的受试者体重不足，33.3％的体重正常，55.6％的体重超重和5.6％的肥胖。尿中双酚A的平均水平显示出从体重过轻到体重超重的趋势。男性和女性群体都强调了相同的趋势。对于肥胖人群，趋势不明显，可能是因为样本量较小。结论我们的结果证实了BPA暴露与体重增加以及广泛的BPA暴露之间的联系，这可能是体重增加的重要危险因素。因此，建议卫生专业人员建议患者减少内分泌干扰物的暴露水平，尤其是在重要的发育时期，例如怀孕，婴儿和青春期。

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