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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Disrupted network topology in patients with Lewy bodies dementia compared to Alzheimer's disease, Parkinson disease dementia and Health Control*
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Disrupted network topology in patients with Lewy bodies dementia compared to Alzheimer's disease, Parkinson disease dementia and Health Control*

机译：与阿尔茨海默病，帕金森病痴呆和健康控制相比，患有石油体痴呆患者的网络拓扑中断，帕金森病痴呆和健康控制 *

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The clinical manifestation of Lewy body dementia (DLB) is distinct from Alzheimer's disease (AD), but overlap with Parkinson's disease dementia (PDD). However, little is known about different topology properties of abnormal brain networks associated with these neurodegenerative diseases. In order to study the difference of brain networks in various dementia subtypes, we used 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG PET) images and graph theory methods to investigate altered whole-brain intrinsic glucose metabolic functional networks in three Chinese dementia groups compared to healthy control (HC) group, including 22 AD patients, 18 PDD patients, 22 DLB patients and 22 HC subjects from Huashan Hospital, Shanghai, China. The experimental results disclosed that in the three dementia groups, compared to HC group, the small-world characteristics were lost. Additionally, compared with HC group, the clustering coefficients of three dementia groups were higher; the characteristic path lengths were longer. In terms of local efficiency and global efficiency, it was at the lowest level in DLB group. We also found differences about distributions of hub regions amongst the four groups. This finding could further help physicians to understand pathological mechanisms of different dementia.
机译：Lewy身体痴呆（DLB）的临床表现与阿尔茨海默病（AD）不同，但与帕金森病痴呆（PDD）重叠。然而，对于与这些神经变性疾病相关的异常脑网络的不同拓扑性质知之甚少。为了研究各种痴呆亚型中脑网络的差异，我们使用了18倍氟脱氧葡萄糖正电子发射断层扫描（18F-FDG PET）图像和图表理论方法，以研究三种中痴呆症组中的改变的全脑内在葡萄糖代谢功能网络比较对健康对照（HC）组，包括22例AD患者，18名PDD患者，22例DLB患者和22名来自中国华山医院的22个HC科目。所公开的实验结果表明，与HC组相比，在三个痴呆组中，小世界特征丧失了。另外，与HC组相比，三个痴呆组的聚类系数较高;特征路径长度较长。就本地效率和全球效率而言，它处于DLB组中的最低水平。我们还发现了四组中枢中心区域的分布差异。这一发现可以进一步帮助医生以了解不同痴呆的病理机制。

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