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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Analysis of adverse effects of stimulation during DBS surgery by patient-specific FEM simulations
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Analysis of adverse effects of stimulation during DBS surgery by patient-specific FEM simulations

机译：患者特异性有限元模拟DBS手术中刺激在刺激的不良反应分析

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Deep brain stimulation (DBS) represents today a well-established treatment for movement disorders. Nevertheless the exact mechanism of action of DBS remains incompletely known. During surgery, numerous stimulation tests are frequently performed in order to evaluate therapeutic and adverse effects before choosing the optimal implantation site for the DBS lead. Anatomical structures responsible for the induced adverse effects have been investigated previously, but only based on stimulation data obtained with the implanted DBS lead. The present study introduces a methodology to identify these anatomical structures during intraoperative stimulation tests based on patient-specific electric field simulations and visualization on the patient specific anatomy. The application to 4 patients undergoing DBS surgery and presenting dysarthria, paresthesia or pyramidal effects shows the different anatomical structures, which might be responsible for the adverse effects. Several of the identified structures have been previously described in the literature. To draw any statistically significant conclusions, the methodology has to be applied to further patients. Together with the visualization of the therapeutic effects, this new approach could assist the neurosurgeons in the future in choosing the optimal implant position.
机译：深脑刺激（DBS）代表今天是运动障碍的良好治疗方法。然而，DBS的确切作用机制仍然不完全了解。在手术期间，经常进行许多刺激测试，以便在为DBS引线选择最佳植入部位之前评估治疗和不利影响。先前研究了负责诱导不良反应的解剖结构，但仅基于用植入的DBS铅获得的刺激数据。本研究介绍了一种方法，以鉴定基于患者特异性电场模拟和患者特异性解剖学的可视化的术中刺激试验期间这些解剖结构。申请4例患者进行DBS手术和呈现讨厌，敏锐度或金字塔效应显示出不同的解剖结构，这可能对不利影响负责。先前已经在文献中描述了几种识别的结构。为了吸引任何统计学意义的结论，必须将方法应用于其他患者。随着治疗效果的可视化，这种新方法可以在未来选择最佳植入物位置时帮助神经外科。

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