The Recognition of Subcellular Localization of Proteins Based on their N-terminal Amino Acid Sequence

机译：基于其N-末端氨基酸序列识别蛋白质的亚细胞定位

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Functional annotation of unknown proteins is a major goal in proteomics. A key annotation is the prediction of a protein's subcellular localization. We used the method of Increment of Diversity with Quadratic Discriminant analysis (IDQD) to predict subcellular localization of proteins which are recognized by the four plant categories and three non-plant and obtained accuracies at 87.4(±0.5)% and 91.2(±0.2)%, respectively in 5-fold cross-validation test. Our result is better than other methods currently published.

机译：未知蛋白质的功能注释是蛋白质组学中的主要目标。关键注释是预测蛋白质的亚细胞定位。我们利用二次判别分析（IDQD）增加了多样性的方法，以预测由四种植物类别和三种非植物识别的蛋白质的亚细胞定位，并在87.4（±0.5）％和91.2（±0.2）下获得的精度（±0.2）％分别在5倍交叉验证测试中。我们的结果比目前发布的其他方法更好。

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《International Conference on Bioinformatics and Biomedical Engineering》|2008年||共4页
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Jia Yun; Zhao Judong; Lu Jun;
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中图分类 G202-53;
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Subcellular localization; Increment of Diversity; Quadratic Discriminant analysis; Amino acid composition; N-terminal targeting signal;

机译：亚细胞定位;多样性增量;二次判别分析;氨基酸组成;N末端靶向信号;

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专利

1. Predicting subcellular localization of proteins based on their N-terminal amino acid sequence. [J] . Emanuelsson O, Nielsen H, Brunak S, Journal of Molecular Biology . 2000,第4期

机译：根据蛋白质的N端氨基酸序列预测蛋白质的亚细胞定位。
2. MultiLoc: prediction of protein subcellular localization using N-terminal targeting sequences, sequence motifs and amino acid composition [J] . Hoglund A, Donnes P, Blum T, Bioinformatics . 2006,第10期

机译：MultiLoc：使用N端靶向序列，序列基序和氨基酸组成预测蛋白质亚细胞定位
3. MultiLoc: prediction of protein subcellular localization using N-terminal targeting sequences, sequence motifs and amino acid composition [J] . Hoglund A, Donnes P, Blum T, Bioinformatics . 2006,第10期

机译：MultiLoc：使用N端靶向序列，序列基序和氨基酸组成预测蛋白质亚细胞定位
4. The Recognition of Subcellular Localization of Proteins Based on their N-terminal Amino Acid Sequence [C] . Jia Yun, Zhao Judong, Lu Jun The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议）论文集 . 2008

机译：基于蛋白质N末端氨基酸序列的蛋白质亚细胞定位识别
5. SUBCELLULAR LOCALIZATION OF GLUTAMIC ACID AND OTHER TRITIUM LABELED-AMINO ACIDS IN CEREBRAL CORTICAL SLICES OF THE RAT. [D] . KUHAR, MICHAEL JOSEPH. 1970

机译：大鼠大脑皮层中谷氨酸和其他T标记的氨基酸的亚细胞定位。
6. Tools for the Recognition of Sorting Signals and the Prediction of Subcellular Localization of Proteins From Their Amino Acid Sequences [O] . Kenichiro Imai, Kenta Nakai 2020

机译：用于识别分选信号的工具及其从氨基酸序列中预测蛋白质的亚细胞定位
7. MultiLoc: prediction of protein subcellular localization using N-terminal targeting sequences, sequence motifs and amino acid composition [O] . A. Hoglund, P. Donnes, T. Blum, 2006

机译：Multiloc：使用N-末端靶向序列，序列基序和氨基酸组成预测蛋白质亚细胞定位
8. 3-D Structure-Based Amino Acid Sequence Alignment of Esterases, Lipases and Related Proteins. [R] . Gentry, M. K., Doctor, B. P., Cygler, M., 1993

机译：基于三维结构的酯酶，脂肪酶和相关蛋白的氨基酸序列比对。

The Recognition of Subcellular Localization of Proteins Based on their N-terminal Amino Acid Sequence

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