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首页> 外文会议>International Conference on Information Technology in Medicine and Education >Sleep Deprivation Increased Dopamine D2 Receptor Expression through Downregulation of miR-9
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Sleep Deprivation Increased Dopamine D2 Receptor Expression through Downregulation of miR-9

机译：睡眠剥夺通过下调miR-9增加多巴胺D2受体表达。

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Sleep-wake cycle is a complex process relates to a variety of neurotransmitters and receptors in the central nervous system (CNS), also involves a large number of gene transcription and translation. MicroRNAs (miRNAs) have emerged as important regulators of gene expression, which mediate translational repression and/or mRNA decay of a target gene. Dopamine D2 receptor (DRD2) gene is predicted as a target gene of a brain-enriched miRNA, miR-9, but their functions in sleep-wake cycle remain unknown. In this study, we reported that REM sleep deprivation decreases the level of miR-9 and this induction is associated with the expression of DRD2 proteins. Thus, miR-9 may control DRD2 gene translation in the prefrontal cortex for processing sleep deprivation. Our findings may have implications in understanding the biological relevance of the genetic associations of sleep disorders. Furthermore, miR-9 may be considered as potential drug targets for the treatment of disorders involving abnormal DRD2 function, such as insomnia.
机译：睡眠-唤醒循环是一个复杂的过程，涉及中枢神经系统（CNS）中的各种神经递质和受体，还涉及大量的基因转录和翻译。微小RNA（miRNA）已经成为基因表达的重要调节剂，其介导目标基因的翻译抑制和/或mRNA衰变。多巴胺D2受体（DRD2）基因被预测为富含大脑的miRNA miR-9的靶基因，但它们在睡眠觉醒周期中的功能仍然未知。在这项研究中，我们报道了REM睡眠剥夺降低了miR-9的水平，并且这种诱导与DRD2蛋白的表达有关。因此，miR-9可能控制前额叶皮层中的DRD2基因翻译，以处理睡眠剥夺。我们的发现可能对理解睡眠障碍遗传关联的生物学相关性有影响。此外，miR-9可能被认为是治疗涉及DRD2功能异常的疾病（例如失眠）的潜在药物靶标。

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