首页> 外文会议>Society for Biomaterials annual meeting and exposition >TUNABLE SPATIOTEMPORAL CONTROL OF ANGIOGENIC AND OSTEOGENIC GROWTH FACTOR DELIVERY VIA HYDROGEL ENCAPSULATION AND COVALENT CONJUGATION
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TUNABLE SPATIOTEMPORAL CONTROL OF ANGIOGENIC AND OSTEOGENIC GROWTH FACTOR DELIVERY VIA HYDROGEL ENCAPSULATION AND COVALENT CONJUGATION

机译:通过水凝胶包合和共价结合对血管性和骨性生长因子的传递进行时空可调控制

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摘要

A new growth factor delivery platform comprising two independent deliver mechanisms, hydrogel encapsulation and covalent conjugation, was used to tune the delivery of an angiogenic (VEGF) and osteogenic (BMP-2) growth factor to correspond with physiological timelines. Tunable release kinetics is achieved in a straightforward manner by tailoring the proportion of each growth factor loaded by each mechanism. Moreover, this platform can be applied to a variety of scaffold biomaterials and other growth factors.
机译:一个新的生长因子传递平台包括两个独立的传递机制,水凝胶封装和共价结合,用于调节血管生成(VEGF)和成骨(BMP-2)生长因子的传递,以适应生理学时间表。通过调整每种机制负载的每种生长因子的比例,可以以直接的方式实现可调的释放动力学。而且,该平台可以应用于多种支架生物材料和其他生长因子。

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