Improving Transdermal Drug Delivery Using Gellan Gum Hydrogels and Temperature Responsive Nanospheres

机译：使用结冷胶水凝胶和温度响应性纳米球改善透皮给药

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In the present work we have developed hydrogel formulations that improves diclofenac transport compared to currently available topical diclofenac gel and solution formulations. Incorporation of diclofenac loaded temperature responsive nanospheres in the hydrogel extends the release time of diclofenac from the hydrogel at skin temperature. The combined use of novel responsive nanomaterials represents an improved approach for controlled delivery of transdermal pharmaceutical preparations.

机译：在本工作中，与目前可用的局部双氯芬凝胶和溶液制剂相比，我们开发了水凝胶制剂，其改善了双氯芬酸的运输。掺入水凝胶中的双氯芬酸负载温度响应纳米球在皮肤温度下从水凝胶中释放双氯芬酸的释放时间。新型响应纳米材料的组合使用代表了一种改进的透皮药物制剂递送的方法。

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《Society for Biomaterials annual meeting and exposition》|2015年|225-225|共1页
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Carlos A. Carmona-Moran; Oleksandra Zavgorodnya; S. Louis Bridges Jr; Robert W Hergenrother; Joanne Murphy-Ullrich; Bernard Ntsikoussalabongui; Andrew D. Penman; Eugenia Kharampieva; Timothy M. Wick;
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1. Development of gellan gum containing formulations for transdermal drug delivery: Component evaluation and controlled drug release using temperature responsive nanogels [J] . Carmona-Moran Carlos A., Zavgorodnya Oleksandra, Penman Andrew D., International Journal of Pharmaceutics . 2016,第1a2期

机译：开发用于透皮药物递送的含吉兰糖胶的制剂：使用温度响应性纳米凝胶进行组分评估和控制药物释放
2. Hydrogels based on gellan gum in cell delivery and drug delivery [J] . Das Madhurima, Giri Tapan Kumar Journal of drug delivery science and technology . 2020,第1期

机译：基于细胞递送和药物递送的Gellan Gum的水凝胶
3. Thermo-and pH-responsive chitosan/gellan gum hydrogels incorporated with the β-cyclodextrin/curcumin inclusion complex for efficient curcumin delivery [J] . Oliveira Ariel C. de, Lima Glayce R. F. de, Klein Rosecler S., Reactive & Functional Polymers . 2021,第Auga期

机译：热和pH-响应壳聚糖/ Gellan Gum水凝胶与β-环糊精/姜黄素包合物复合物，用于有效姜黄素递送
4. Improving Transdermal Drug Delivery Using Gellan Gum Hydrogels and Temperature Responsive Nanospheres [C] . Carlos A. Carmona-Moran, Oleksandra Zavgorodnya, S. Louis Bridges, Society for Biomaterials Annual Meeting and Exposition . 2015

机译：使用Gellan Gum水凝胶和温度响应纳米球改善透皮药物递送
5. Microbead embedded hydrogel as drug reservoir for transdermal macromolecular drug delivery. [D] . Amsden, Brian Gregory. 1996

机译：微珠嵌入水凝胶作为透皮大分子药物递送的药物储库。
6. Gellan Gum-Based Hydrogel for the Transdermal Delivery of Nebivolol: Optimization and Evaluation [O] . Anroop B. Nair, Jigar Shah, Bader M. Aljaeid, 2019

机译：吉兰糖基水凝胶用于奈必洛尔的透皮给药：优化和评估
7. Gellan Gum-Based Hydrogel for the Transdermal Delivery of Nebivolol: Optimization and Evaluation [O] . Jigar Shah, Bandar E. Al-Dhubiab, Shery Jacob, 2019

机译：基于Gellan Gum的水凝胶，用于Nebivolol的透皮递送：优化和评估

Improving Transdermal Drug Delivery Using Gellan Gum Hydrogels and Temperature Responsive Nanospheres

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