Synthesis of Cobalt Crosslinked Albumin Nanoparticles and In Vitro Evaluation of Macropinocytic Uptake in Gastric Carcinoma Cells

机译：钴交联白蛋白纳米粒子的合成及胃癌细胞中大细胞摄取的体外评价

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Accordingly, this study demonstrated three key outcomes: first, cancer cells efficiently internalize Co-Alb NPs while displaying high levels of macropinocytic uptake; second, Co-Alb NPs show biocompatibility and potential as a drug delivery vector through demonstrating no toxcity; third, because SNU-5 cells are not known to harbor Ras mutations, this study shows that some non-Ras mutated tumor types also rely on macropinocytosis as a mechanism of cell survival.

机译：因此，这项研究证明了三个关键结果：首先，癌细胞有效地内化了Co-Alb NP，同时表现出高水平的大细胞摄取。第二，Co-Alb NPs通过显示无毒性显示出生物相容性和作为药物传递载体的潜力。第三，由于尚不知道SNU-5细胞具有Ras突变，因此这项研究表明，某些非Ras突变的肿瘤类型也依赖巨胞饮作为细胞存活的机制。

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《Society for Biomaterials annual meeting and exposition》|2015年|540-540|共1页
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Ronaldo J. Cavazos Jr.; Clifford S. Morrison; Jana B. Lampe; Duong T. Nguyen; Alesha N. Harris; Brian K. McFarlin; Robby A. Petros;
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4. Synthesis of Cobalt Crosslinked Albumin Nanoparticles and In Vitro Evaluation of Macropinocytic Uptake in Gastric Carcinoma Cells [C] . Ronaldo J. Cavazos, Clifford S. Morrison, Jana B. Lampe, Society for Biomaterials Annual Meeting and Exposition . 2015

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Synthesis of Cobalt Crosslinked Albumin Nanoparticles and In Vitro Evaluation of Macropinocytic Uptake in Gastric Carcinoma Cells

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