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Similarities found in neurological disorders based on mutated genes

机译：基于突变基因的神经系统疾病发现相似之处

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According to the UN World Health Organization, nearly one in every six of the world's population is affected by a neurological disorder. This research study focused on neural networks and analyzed the connections between neurological disorders defined by similar single nucleotide polymorphisms (SNP). By utilizing the Genome-wide Association studies, SNPs associated with a select group of neurological disorders were identified. Drug molecules that target these SNPs were gathered from the DrugBank. The results showed that Schizophrenia and Bipolar disorder were the most genetically similar based on the SNPs associated with them. Also, Schizophrenia had the highest number of SNPs associated with it as well as the highest betweenness rank. The gene TRNAI25 was the gene found among four of the disorders and it is implicated in various biological roles such as coding, decoding, regulation, and expression of genes. The drug, Felodipine, targets two SNPs, one associated with Schizophrenia and the other with Bipolar Disorder. Neurological disorders are being visualized through patient CT or MRI scans; however, this study focused on the shared SNPs in different neurological disorders generated from preexisting data. With this project, genetic similarities were found within a select group of neurological disorders and may further biological research in neurological disorders through the use of network science.
机译：根据联合国世界卫生组织的统计，世界上近六分之一的人口患有神经系统疾病。这项研究专注于神经网络，并分析了由相似的单核苷酸多态性（SNP）定义的神经系统疾病之间的联系。通过利用全基因组关联研究，可以确定与一组特定的神经系统疾病相关的SNP。靶向这些SNP的药物分子是从DrugBank收集的。结果表明，基于与精神分裂症和双相情感障碍相关的SNP，它们在遗传上最相似。而且，精神分裂症具有与其相关的最高SNP数目以及最高的中间度等级。 TRNAI25基因是在四种疾病中发现的基因，与多种生物学作用有关，例如基因的编码，解码，调控和表达。该药物非洛地平靶向两种SNP，一种与精神分裂症有关，另一种与躁郁症有关。通过患者的CT或MRI扫描可以看到神经系统疾病。然而，这项研究的重点是从现有数据中产生的不同神经系统疾病中的共享SNP。通过该项目，在一组特定的神经系统疾病中发现了遗传相似性，并可能通过使用网络科学进一步对神经系统疾病进行生物学研究。

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