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Biomolecular Annotation Integration and Querying to Help Unveiling New Biomedical Knowledge

机译:生物分子注释集成和查询,以帮助揭示新的生物医学知识

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Targeting biological questions requires comprehensive evaluation of multiple types of annotations describing current biological knowledge; they are increasingly available, but their fast evolution, heterogeneity and dispersion in many different sources hamper their effective use. Leveraging on innovative flexible data schema and automatic software procedures that support the integration of data sources evolving in number, data content and structure, while assuring quality and provenance tracking of the integrated data, we created a multi-organism Genomic and Proteomic Knowledge Base (GPKB) and easily maintained it updated. From several well-known databases it imports and integrates very numerous gene and protein data, external references and annotations, expressed through multiple biomedical terminologies. The created GPKB is a very valuable resource used in several projects by many users; the developed interfaces enhance its relevance to the community by allowing the seamlessly composition of queries, although complex, on all data integrated in the GPKB, which can help unveiling new biomedical knowledge.
机译:针对生物学问题需要对描述当前生物学知识的多种类型注释进行全面评估;它们越来越多,但它们的快速发展,异质性和在许多不同来源中的分散性阻碍了它们的有效使用。利用创新的灵活数据模式和自动软件程序,该软件程序支持数量,数据内容和结构不断变化的数据源的集成,同时确保对集成数据的质量和出处的跟踪,我们创建了一个多基因组和蛋白质组学知识库(GPKB) ),并轻松对其进行更新。它从几个著名的数据库中导入并整合了通过多种生物医学术语表达的大量基因和蛋白质数据,外部参考文献和注释。创建的GPKB是许多用户在多个项目中使用的非常有价值的资源。开发的界面通过允许对GPKB中集成的所有数据的查询(尽管很复杂)进行无缝组合,从而增强了其与社区的相关性,这可以帮助揭示新的生物医学知识。

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