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首页> 外文会议>Conference on multimodal biomedical imaging >Multimodal imaging of ocular surface of dry eye subjects
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Multimodal imaging of ocular surface of dry eye subjects

机译：干眼受试者眼表的多峰成像

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To study the relationship between the corneal lipid layer and the ocular surface temperature (OST), we conducted a clinical trial for 20 subjects. Subjects were clinically screened prior to the trial. Of the 20 subjects, 15 have Meibomian gland dysfunction (MGD), and 5 have aqueous-deficient dry eye (ADDE). A custom, circularly polarized illumination video tearscope measured the lipid layer thickness of the ocular tear film. A long-wave infrared video camera recorded the dynamic thermal properties of the ocular team film. The results of these two methods were analyzed and compared. Using principal component analysis (PCA) of the lipid layer distribution, we find that the 20 subjects could be categorized into five statistically significant groups, independent of their original clinical classification: thin (6 subjects), medium (5 subjects), medium and homogenous (3 subjects), thick (4 subjects), and very thick (2 subjects) lipids, respectively. We also conducted PCA of the OST data, and recategorized the subjects into two thermal groups by k-means clustering: one includes all ADDE subjects and some MGD subjects; the other includes the remaining MGD subjects. By comparing these two methods, we find that dry eye subjects with thin (≤ 40 nm) lipids have significantly lower OST, and a larger OST drop range, potentially due to more evaporation. However, as long as the lipid layer is not thin (＞ 40 nm), there is no strong correlation between the lipid layer thickness and heterogeneity and the OST patterns.
机译：为了研究角膜脂质层与眼表温度（OST）之间的关系，我们进行了20位受试者的临床试验。在试验之前对受试者进行临床筛选。在这20名受试者中，有15名患有睑板腺功能障碍（MGD），而5名患有缺水性干眼症（ADDE）。定制的圆偏振照明视频泪液镜可测量眼泪膜的脂质层厚度。一台长波红外摄像机记录了目镜组胶片的动态热性能。分析和比较了这两种方法的结果。使用脂质层分布的主成分分析（PCA），我们发现20名受试者可以分为五个统计学上显着的组，而与他们最初的临床分类无关：瘦（6名受试者），中等（5名受试者），中等和均质（3个受试者），浓稠的（4个受试者）和非常浓稠的（2个受试者）脂质。我们还对OST数据进行了PCA，并通过k均值聚类将受试者分为两个热组：一个包括所有ADDE受试者和一些MGD受试者。另一个包括其余的MGD科目。通过比较这两种方法，我们发现脂质稀薄（≤40 nm）的干眼受试者的OST显着降低，而OST下降范围更大，这可能是由于更多的蒸发。但是，只要脂质层不薄（> 40 nm），脂质层的厚度与异质性和OST模式之间就没有很强的相关性。

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