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首页> 外文会议>International Conference on Nanotechnology >Green synthesis of gold nanoparticles from the rind extract of Garcinia mangostana and its synergistic effect with antibiotics against human pathogenic bacteria
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Green synthesis of gold nanoparticles from the rind extract of Garcinia mangostana and its synergistic effect with antibiotics against human pathogenic bacteria

机译：Glind提取物从Garcinia Mangostana的RIND提取物的绿色合成及其对人致病菌抗生素的协同作用

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The present investigation reports a facile method for the biosynthesis of gold nanoparticles from the rind extract of Garcinia mangostana, a medicinal plant which acts as a reducing agent. It was observed that the aqueous gold ions, when exposed to the rind extract of G.mangostana were reduced in the solution, thereby leading to the formation of gold nanoparticles (GMREGNP). The structural characterization was performed using HR-TEM; the micrographs showed the well dispersed spherical nanoparticles ranged from 25 - 60 nm. The SAED diffraction rings suggested that the GMREGNP were polycrystalline in nature. The peaks in the XRD were in good agreement with the standard values of the spherical form of metallic gold and no peaks of impurities were detected. From the Fourier Transformed-Infrared Spectra (FT-IR) of the rind extract and phytosynthesised gold nanoparticles, the possible functional groups involved in the gold ions reduction and capping of the gold nanoparticles were identified. The particle size (DLS) and the electro kinetic measurement (zeta potential) of the GMREGNP was also evaluated. The nanoparticles were assessed for their increased antimicrobial activity with various antibiotics against potential human pathogens. Further the fabrication of the bio-inspired GMREGNP with the drug and the changes on the characteristics of the nanoparticles were studied using various techniques like UV-VIS spectroscopy and FT-IR. The minimal inhibitory concentration (MIC) of the GMREGNP and drug fabricated GMREGNP has been recorded. The topological changes stamped by the nanoparticles on the surface of the bacteria have been recorded by SEM images. Experiments are underway to prove the possible mechanism for the synergistic effect of the nanoparticles with antibiotics.
机译：本研究报告了一种易于用作还原剂的药用植物的RIND提取物的金纳米颗粒的生物合成方法。据观察，所述水性金离子，当暴露于G.mangostana的果皮提取物在溶液中均减少，从而导致金纳米粒子的形成（GMREGNP）。使用HR-TEM进行结构表征;显微照片显示出井分散的球形纳米颗粒，范围为25-60nm。起草衍射环表明GMRENP本质上是多晶。 XRD中的峰与金属金的球形形式的标准值吻合良好，没有检测到杂质的峰。从外皮提取物和植酸的红外光谱（FT-IR）的傅里叶变换 - 红外光谱（FT-IR），鉴定了金离子还原和金纳米颗粒的封端的可能官能团。还评估了GMREGNP的粒度（DLS）和电动动力学测量（Zeta电位）。评估纳米颗粒的抗微生物活性与各种抗生素对抗潜在的人病原体。进一步使用紫外 - Vis光谱和FT-IR等各种技术研究了与药物的生物启发的GMREANP和纳米颗粒特性的变化的制备。已经记录了GMRENPP和药物制造的GMRENPP的最小抑制浓度（MIC）。通过SEM图像记录由纳米颗粒印花的拓扑变化已经记录过SEM图像。实验正在进行实验，以证明纳米粒子与抗生素协同作用的可能机制。

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