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Study Design and Implementation Approaches for Conducting Population-Based Studies Near Oil and Natural Gas Development Sites: A Case Study from the Denver Julesburg Basin

机译:在石油和天然气开发基地附近开展基于人群的研究的研究设计和实施方法:以丹佛·朱尔斯堡盆地为例

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The process of estimating exposure and health risk from the wide range of stressors present near oil and gas development (OGD) sites in communities is complex. This is partially due to the recent changes in production practices, recent shifts in the intensity of development, and the challenge of recruiting a representative sample of subjects from the population at risk. In this presentation, we discuss the study design deployed to evaluate differences in exposure and response to chemical and nonchemical stressors from OGD in two Colorado communities in the Denver Julesburg Basin. Our multifaceted study design used community level surveys, measurement of biomarkers of subclinical effects, and community noise and air monitoring to obtain data on chemical and non-chemical stressor exposure and response in both communities. Challenges in implementing the study included uncertainty introduced by the recent reduction in the pace OGD and varying levels of subject willingness to participate in the two communities. Using examples from our work we describe strategies to address these design and implementation challenges, discuss results, and present our approach to communicating our results to community partners and other stakeholders.
机译:从社区中油气开发(OGD)地点附近存在的各种压力源估算暴露和健康风险的过程很复杂。这部分是由于生产方式的最新变化,发展强度的最新变化以及从有风险的人群中招募代表性样本的挑战。在本演示中,我们讨论了研究设计,该研究设计用于评估丹佛·朱尔斯堡盆地两个科罗拉多社区中OGD对化学和非化学应激源的暴露和响应差异。我们的多方面研究设计使用了社区水平的调查,亚临床效应生物标志物的测量以及社区噪音和空气监测,以获取有关两个社区中化学和非化学应激源暴露和反应的数据。实施研究的挑战包括OGD步伐的近期降低以及受试者参与这两个社区的意愿水平的差异带来的不确定性。使用我们工作中的示例,我们描述了应对这些设计和实施挑战,讨论结果并提出将结果传达给社区合作伙伴和其他利益相关者的策略。

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