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首页> 外文会议>Annual conference of the International Society of Exposure Science >ECETOC TRA FOR WORKERS: Lessons learned from its use under reach
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ECETOC TRA FOR WORKERS: Lessons learned from its use under reach

机译：ECETOC TRA for WORKS：触手可及的使用经验

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Introduction: The ECETOC Targeted Risk Assessment (TRA) model for workers is intended to evaluate the risks for workers arising from the manufacture and use of chemicals. The versions 2 and 3 of the model have been extensively used for worker chemical safety assessments during the first and second REACH registration phases (2007-2013). The model is also incorporated in the ECHA CHESAR tool (Chemical Safety and Reporting tool). The version 3 model was developed based on the solicited feedback from TRA users on their experiences with the tool in the 2009-2011 period, as well as the feedback by ECHA (integration into CHESAR). Since 2014 ECETOC is working closely with ECHA to improve the guidance on the application (domain) of the tool and to investigate the need for future modifications. This was prompted by ECHA and industry experiences with the application of the tool in Chemical Safety Assessments, and the updates of the ECHA guidance documents on use description and on occupational exposure assessment. Results: For version 3, the suggestions received from users have resulted in the implementation of improvements in the core of the model (exposure estimates), as well as in related exposure determinants (operational conditions and risk management measures). The cooperation between ECETOC and ECHA has led, among others, to more precise description of PROC's (Process Categories),better guidance on PROC-assignment for modeled activities, improved clarifications of the applicability domain (e.g. PROC's for closed systems, and substances of very high concern), as well as a more transparent approach to address elevated operation temperature. These improvements are partly built into the new CHESAR version (V3.0) and are reflected in the updates of the ECHA guidance documents. The decision to develop an updated version of the model is pending the analysis of the results of the ETEAM study (Evaluation of Tier 1 Exposure Assessment Models) and the results of a limited dermal exposure assessment validation study. Discussion: The discussion will address the experiences and challenges with implementation of proposed modifications of the model and further definition of its application (domain). Examples are the balancing of user requests/expectations for enhancements versus principles to maintain its Tier 1 characteristics and scientific integrity, the pros/cons of adaptation of the model during its application within the REACH implementation timelines, the level of training/expertise required for users to adequately apply the model, and securing consistency of model application/outcomes in different settings (stand-alone tool versus integration in CHESAR).
机译：简介：针对工人的ECETOC目标风险评估（TRA）模型旨在评估由于化学品生产和使用而给工人带来的风险。该模型的版本2和版本3已在REACH的第一和第二注册阶段（2007-2013）广泛用于工人的化学安全性评估。该模型还包含在ECHA CHESAR工具（化学安全和报告工具）中。根据TRA用户在2009年至2011年期间对该工具使用经验的征求反馈意见以及ECHA（集成到CHESAR）的反馈意见，开发了版本3模型。自2014年以来，ECETOC与ECHA紧密合作，以改善对该工具的应用程序（领域）的指导，并研究未来修改的需求。 ECHA和该工具在化学安全评估中的应用经验以及有关使用说明和职业接触评估的ECHA指导文件的更新，都促使了这一点。结果：对于版本3，从用户那里收到的建议导致对模型核心（暴露估计）以及相关的暴露决定因素（操作条件和风险管理措施）进行了改进。 ECETOC和ECHA之间的合作，除其他外，导致对PROC（过程类别）进行了更精确的描述，为模拟活动分配了PROC更好的指导，改进了适用领域的澄清（例如，封闭系统的PROC，以及非常危险的物质）。高度关注），以及解决工作温度升高的更透明方法。这些改进部分内置于新的CHESAR版本（V3.0）中，并反映在ECHA指导文档的更新中。开发模型更新版本的决定有待对ETEAM研究（一级暴露评估模型的评估）的结果和有限的皮肤暴露评估验证研究的结果进行分析。讨论：讨论将解决实施模型的拟议修改以及进一步定义其应用（领域）的经验和挑战。例如，用户对增强的要求/期望与保持其第1层特性和科学完整性的原则之间的平衡，模型在REACH实施时间表内的应用过程中适应的利弊，用户所需的培训/专业水平以充分应用模型，并确保模型应用程序/结果在不同设置下的一致性（独立工具与CHESAR中的集成）。

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