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首页> 外文会议>International astronautical congress >INFLUENCE OF THE ABSORBED DOSE OF SPACE RADIATION ON BIOCHEMICAL PARAMETERS OF BLOOD DURING LONG-TERM SPACE FLIGHTS ON THE RUSSIAN SEGMENT OF THE INTERNATIONAL SPACE STATION
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INFLUENCE OF THE ABSORBED DOSE OF SPACE RADIATION ON BIOCHEMICAL PARAMETERS OF BLOOD DURING LONG-TERM SPACE FLIGHTS ON THE RUSSIAN SEGMENT OF THE INTERNATIONAL SPACE STATION

机译：空间辐射的吸收剂量对国际空间站俄罗斯分段长期飞行过程中血液生化参数的影响

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The main objective of the present research aimed to estimate the possible influence of individual absorbed doses of space radiation (ADSR) by the Russian cosmonauts (n=14) on their blood biochemistry during long-term space flights (SF) of 1-10 and 16 basic missions on Russian segment of ISS. The total and current ADSR to dates of onboard blood analyses (30-182 days of SF, n = 21) varied from 2,2 to 4,0 and from 0,51 to 3,19 cGy for one crewmember, correspondingly, according to individual dosimetry control data (dosimeters ID-3). The linear correlation analyses (Spearmen and Pearson) showed very high relationships between SF duration and total ADSR (r=0,835, p<0.0001), moderate - for SF duration with mean proton fluxes (PF) energy during flight (R=0,505, p=0,02), and for ADSR to dates of analyses with mean PF energy during the period from launch up to analyses dates (r=0,552, p=0.009), and not revealed any significant links of blood biochemistry with ADSR. During more complex statistical data processing the ADSR (as one of independent variables along with anthropometry and dates of onboard biochemical analyses of blood = days of SF) made moderate to low but the significant contribution into the equations of multiple regression when dependent variables were in turn blood concentrations of hemoglobin, glucose, uric acid, alanine-aminotransferase, amylase and creatine-phosphokinase. The received results, first, indicate on the influence of ADSR on the blood biochemical parameters during SF but less than age, mode of work and rest, fluid shifts, hypotrophic processes in muscles, low physical activity, changes in lipid and carbohydrate metabolism and other microgravity manifestations, and, second, evidenced of good level of onboard radioprotection as estimated parameters of blood biochemistry, characterizing functional activity and state of main organs and physiological systems, varied mainly within normal physiological range even at the presence of Solar Particle Events during observed period (2001-2005 years).
机译：本研究的主要目的旨在估计俄罗斯宇航员（n = 14）在1至10的长期太空飞行（SF）期间对俄罗斯宇航员（n = 14）吸收的单个空间辐射剂量（ADSR）对其血液生化的可能影响。对国际空间站俄罗斯部分进行16次基本任务。根据机上血液分析的日期，总的和当前的ADSR（SF的30-182天，n = 21）分别从2,2到4,0，从0.51到3,19 cGy不等。各个剂量控制数据（剂量计ID-3）。线性相关分析（Spearmen和Pearson）显示SF持续时间与总ADSR之间有非常高的关系（r = 0,835，p <0.0001），中等-SF持续时间与飞行过程中的平均质子通量（PF）能量（R = 0,505，p = 0,02），并且对于从开始到分析日期这段时间内的ADSR到具有平均PF能量的分析日期（r = 0,552，p = 0.009），并且没有揭示血液生物化学与ADSR的任何显着联系。在更复杂的统计数据处理过程中，ADSR（作为人体变量和船上血液学生化分析的独立变量之一，即血液的天数= SF天数）从中到低，但是当因变量依次出现时，对多元回归方程的贡献很大血液中的血红蛋白，葡萄糖，尿酸，丙氨酸转氨酶，淀粉酶和肌酸磷酸激酶的浓度。接收到的结果首先表明了ADSR对SF期间血液生化参数的影响，但小于年龄，工作和休息方式，体液移位，肌肉营养不良过程，低体力活动，脂质和碳水化合物代谢变化等微重力的表现，其次，作为估计的血液生物化学参数，表征功能活性以及主要器官和生理系统的状态，证明了机载放射防护水平良好，即使在观察期内存在太阳粒子事件，也主要在正常生理范围内变化（2001-2005年）。

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