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首页> 外文会议>International conference on electrophoretic deposition: fundamentals and applications >ANTIBACTERIAL AND BIOACTIVE COATINGS BASED ON ELECTROPHORETIC DEPOSITION OF CHITOSAN/BIOACTIVE GLAS/LAWSONE ON PEEK/BIOACTIVE GLASS LAYERS
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ANTIBACTERIAL AND BIOACTIVE COATINGS BASED ON ELECTROPHORETIC DEPOSITION OF CHITOSAN/BIOACTIVE GLAS/LAWSONE ON PEEK/BIOACTIVE GLASS LAYERS

机译：基于聚醚醚酮/生物玻璃层上壳聚糖/生物玻璃/紫胶的电泳沉积的抗菌和生物涂层

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The electrophoretic deposition (EPD) is an attractive approach for development of Polyether ether ketone (PEEK) and 45S5 bio-active glass (BG®) composite coatings for biomedical applications. However, in order to establish the influence of the EPD parameters on the properties of the deposited coatings, a deeper investigation of the fundamental PEEK/BG co-EPD kinetics is required. Previous studies have reported hit and trial approach in order to optimize key EPD parameters, which is material and time consuming. Therefore, in this study, design of experiment approach was utilized to reach the optimized parameters economically. Accordingly, the PEEK/BG-EPD kinetics was established as a function of deposition time and voltage, accompanied by microscopic characterization of the deposited films. The experimental results showed that the deposition follows a linear growth law, in good agreement with the predictions of Hamaker's law. The green coatings produced from the optimized set of parameters were sintered, in order to achieve substantial adhesion to the metallic substrate. Moreover, Chitosan/BG/Lawson composite was also deposited electrophoretically by optimized set of parameters on the sintered PEEK/BG composite coatings. Produced multilayer coatings attain multifunctional attributes; such as mechanical integrity and bioactivity from first layer, whereas, bioresorbable chitosan in top layer provided an effective platform to trigger the release of antibacterial drug (Lawson). The morphology of multilayer coatings was examined by using scanning electron microscopy (SEM), elemental and compositional analysis was performed qualitatively with energy-dispersive x-ray spectroscopy (EDX) and x-ray diffraction (XRD), respectively. Fourier transformed infrared spectroscopy (FTIR) was employed in order to identify the chemical structure of multilayer coatings. Moreover, wettability of the multilayer coatings was analyzed by static water contact angle measurements. Finally, in vitro bioactivity was assessed by immersing the multilayer coatings in simulated body fluid for 3, 7 and 14 days. The developed multilayer coatings were fairly homogenous, micro-porous and moderately hydrophobic. Furthermore, multilayer coatings were covered completely with apatite like layer after 3 days of immersion in SBF.
机译：电泳沉积（EPD）是开发用于生物医学应用的聚醚醚酮（PEEK）和45S5生物活性玻璃（BG®）复合涂层的一种有吸引力的方法。然而，为了确定EPD参数对沉积涂层性能的影响，需要对基本的PEEK / BG共EPD动力学进行更深入的研究。先前的研究已经报道了命中和尝试方法，以优化关键的EPD参数，这既耗时又费时。因此，在这项研究中，实验方法的设计被用来经济地达到最佳参数。因此，建立了PEEK / BG-EPD动力学与沉积时间和电压的函数关系，并伴随着沉积膜的微观表征。实验结果表明，沉积遵循线性增长定律，与Hamaker定律的预测吻合良好。烧结由优化的一组参数产生的生坯涂层，以实现对金属基材的充分粘附。此外，壳聚糖/ BG / Lawson复合材料还通过优化的一组参数电泳沉积在烧结的PEEK / BG复合涂层上。生产的多层涂料具有多功能特性;例如第一层的机械完整性和生物活性，而顶层的可生物吸收的壳聚糖提供了触发抗菌药物释放的有效平台（劳森）。使用扫描电子显微镜（SEM）检查了多层涂层的形貌，分别通过能量色散X射线光谱（EDX）和X射线衍射（XRD）进行了定性和元素分析。为了确定多层涂层的化学结构，采用了傅里叶变换红外光谱（FTIR）。此外，通过静态水接触角测量来分析多层涂层的润湿性。最后，通过将多层涂层浸入模拟体液中3、7和14天来评估体外生物活性。所开发的多层涂层是相当均匀的，微孔的和中等疏水性的。此外，在SBF中浸泡3天后，多层涂层完全被磷灰石样层覆盖。

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