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首页> 外文会议>Annual conference of the International Society of Exposure Science >The Fernald Community Cohort: Lessons Learned from a Large Environmental Epidemiology Cohort with a 25 Year Heritage
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The Fernald Community Cohort: Lessons Learned from a Large Environmental Epidemiology Cohort with a 25 Year Heritage

机译：Fernald社区队列：从拥有25年遗产的大型环境流行病学队列中学到的经验教训

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Background: Members of the Fernald Community Cohort (FCC, N=9782) received medical screenings from 1990-2008 (18 years). Although eligibility for the medical monitoring program was based on living within 5 miles of a uranium refinery, exposure dosimetry studies conducted by CDC demonstrated that much of the cohort never experienced uranium exposure beyond usual background levels, and thus there are both uranium-exposed and non-exposed persons in the cohort. Cohort follow-up continues to the present. Methods: Members of this multi-generational cohort completed yearly questionnaires (total 96,091) on a wide array of health risk factor and broad exposure information and received a comprehensive medical examination every 2 or 3 years (total 43,283) including clinical laboratory tests, mammograms, PFTs, EKGs, and chest x-rays. Over 160,000 aliquots of blood and urine samples are stored in -80 freezers. Cohort members gave broad consent for use of their data and biospecimens for future research, and data and biospecimen sharing was implemented in 2001, with multiple improvements to the policy over time with experience in resource sharing. Results: Data are coded and reside in a SAS database linked to the biospecimen repository. Learnings include planning early for extensive protocol and data documentation including a searchable data dictionary, a biospecimen inventory system and quality assurance procedures, actively encouraging and tracking publication of study findings, and budgeting for cohort maintenance and enhancement costs into the future. Seventy-six research projects have resulted in 38 published manuscripts, reporting the findings of studies of uranium and other environmental exposures, such as perfluoroalkyl compounds and bisphenol-A, and predictive biomarkers for breast, lung, prostate cancer, and abdominal aortic aneurysm. http://med.uc.edu/eh/research/projects/fcc. The FCC is registered with ClinicalTrials.gov. Funding: P30-ES006096, R834788, T32ES10957
机译：背景：Fernald社区队列（FCC，N = 9782）的成员从1990年至2008年（18岁）接受了医学检查。尽管是否有资格进行医学监测计划是基于居住在铀精炼厂5英里范围内的，但疾病预防控制中心进行的剂量学研究表明，大部分人群从未经历过超出正常背景水平的铀暴露，因此铀暴露和非铀暴露均如此。队列中接触过的人。队列随访一直持续到现在。方法：该多代队列研究的成员完成了关于各种健康风险因素和广泛暴露信息的年度问卷调查（总计96,091份），并且每2或3年接受了全面的医学检查（总计43,283份），包括临床实验室检查，乳房X线照片， PFT，EKG和胸部X光片。超过160,000等份血液和尿液样本存储在-80个冰柜中。队列成员广泛同意将其数据和生物标本用于未来研究，并于2001年实施了数据和生物标本共享，并随着时间的推移在资源共享方面取得了多项政策上的改进。结果：数据被编码并驻留在链接到生物样本存储库的SAS数据库中。学习内容包括及早规划广泛的协议和数据文档，包括可搜索的数据字典，生物样本清单系统和质量保证程序，积极鼓励和跟踪研究结果的发表，以及为将来的队列维护和增强成本进行预算。七十六个研究项目产生了38篇已发表的手稿，报告了铀和其他环境暴露的研究结果，例如全氟烷基化合物和双酚A，以及乳腺癌，肺癌，前列腺癌和腹主动脉瘤的预测性生物标志物。 http://med.uc.edu/eh/research/projects/fcc。 FCC已在ClinicalTrials.gov上注册。资金：P30-ES006096，R834788，T32ES10957

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